Treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NET) is still unsatisfactory and innovative therapeutic approaches are urgently needed. Heat shock protein 90 (Hsp90) is overexpressed in a wide range of tumor types and is an emerging target for the treatment of cancer. However, the potential activity of Hsp90 inhibitors in GEP-NET ha...

The activity of the receptor tyrosine kinase KIT is crucial for gastrointestinal stromal tumor (GIST) growth and survival. Imatinib and sunitinib are very effective in advanced GIST, but have no curative potential. The observation that heat shock protein 90 (HSP90) inhibition results in KIT degradation prompted us to assess the efficacy of the HSP90 inhibitor retaspimycin hydrochloride (IPI-504...

conclusions both task-related and resting fmri techniques have the potential to detect early brain dysfunction related to ad. however, the use of fmri in ad populations thus far has been limited to a relatively small number of research groups. results bold fmri is considered to reflect the joined synaptic activity of neurons through mri signal changes because of alterations in blood flow, blood...

Direct imaging observations of the solar-type star Gl 504 have recently uncovered a faint companion that, on the supposition that the host star has an age of + 160 60 350 Myr, was announced to be a + 4 1.0 4.5 MJ Jovian exoplanet. Here we present the observational evidence that Gl 504 A is an evolved turn-off star of about solar age and by inference its faint companion a low-mass brown dwarf. A...

The aim of this study was to investigate the association between the mutation of multidrug resistance 3 (MDR3) exon 6 and parenteral nutrition-associated cholestasis (PNAC) in preterm infants. A total of 41 preterm infants with PNAC formed the experimental group, and 56 preterm infants receiving total parenteral nutrition (TPN) for >14 days but without cholestasis formed the control group. Geno...

abstract this study was conducted with the objective of investigating the practice of teaching early reading comprehension. the study was carried out in sixty-six grade 2 government primary schools found in snnpr state in gedeo zone,ethiopia, in the academic year 2015. sixty-six english language teachers were subjects of the study. the study employed mixed method, specifically quant-qual one. d...

In their seminal paper Fuhrer and Moore (1995) provide an explanation for the existence of inflation inertia. Driscoll and Holden (2003) argue that under more plausible assumptions the model of Fuhrer and Moore (1995) will coincide with the model of Taylor (1979) which can only explain sticky prices but not sticky inflation. Following the suggestions by Driscoll and Holden (2003) we extend thei...