BACKGROUND Drug-eluting balloons (DEB) may be promising technology for treating atherosclerotic arterial disease. In fact, several DEBs have been clinically available for the treatment of coronary in-stent restenosis (ISR), de novo coronary lesions, and peripheral artery disease. OBJECTIVE We sought to elucidate the mechanism of action and in vivo safety and efficacy of a novel iopromide-base...

D isturbed eating behavior (DEB), which includes subthreshold and full-syndrome eating disorders (EDs) as well as milder eating disturbances, is more common in girls and women with type 1 diabetes than in their nondiabetic peers (1,2). DEB is associated with poorer metabolic control (1,3) and increased hospitalizations and diabetesrelated medical complications (4–7). At baseline of the present ...

BACKGROUND Most cases of hyponatremia--serum sodium concentration ([Na+]) < 135 mEq/l (< 135 mM)--are associated with an elevated plasma arginine vasopressin level. This study investigated the efficacy and tolerability of intravenous conivaptan (YM087), a vasopressin V1A/V2-receptor antagonist, in treating euvolemic and hypervolemic hyponatremia. METHODS Eighty-four hospitalized patients with...

Matricaria chamomilla is a medicinal plant that is widely cultivated in salt affected soils. This investigation was undertaken to study the effect of NaCl concentration on germination, and the physiological, biochemical and growth characteristics of chamomile. Seed germination and growth were studied at five NaCl concentration levels (0, 40, 80, 120 and 190 mM NaCl concentration). Increasing th...

Mitogens and vasoconstrictors stimulate many of the same early intracellular signals (e.g. phospholipase C and protein kinase C activation) in vascular smooth muscle cells (VSMC). Despite these shared signals, angiotensin II is not mitogenic for cultured VSMC. The nonmitogenic effect of angiotensin II suggests that other intracellular signals associated with growth should differ between mitogen...

H yponatremia represents a serious health hazard. 1 Hospitalized patients, nursing home residents, women, and children exhibit high frequency and/or severity of hyponatremia. Hyponatremia developing during the course of other morbid conditions increases their severity. Estimates of direct costs for treating hyponatremia in the United States ranged between $1.61 and $3.6 billion. Clinical manife...