It has been suggested that translocations, and perhaps other chromosome rearrangements, disturb meiotic disjunction of uninvolved chromosome pairs and predispose to trisomic offspring. If so, then one would expect an excess of translocations not involving chromosome 21 among the parents of regular trisomic Down's syndrome patients. Such translocations have been reported, but mostly as anecdotal...

A retrospective analysis was performed on 1102 cases with a provisional diagnosis of Down syndrome referred to the Department of Genetics, Dr.ALMPGIBMS, University of Madras during the period from 1979 to 2006. Cytogenetic analyses confirmed the diagnosis in 1020 cases (92.6%). Among them, regular (free) trisomy 21 constituted 83.82 percent. Mosaicism was recorded in 10.78% and Robertsonian tra...

Purpose
 A number of mechanisms have been proposed for the effect chromosomal translocations on spermatogenesis and sperm maturation. However, there are still numerous ambiguous issues regarding these two processes. The aim this study is to evaluate chromosome break areas count in light literature.
 Material Methods
 was conducted data 16 male patients with reciprocal or Robertso...

Robertsonian and reciprocal chromosomal translocations are the most frequent type of structural chromosomal aberrations in the human population. We report the frequency and type of detected translocations in 10 years of prenatal diagnosis of 3800 prenatal samples. The materials came from amniocentesis and chorionic villus samples (CVS). We detected seven Robertsonian translocations (0.18%), eig...

The frequency of the Robertonian (ROB) translocation in newborn babies is approximately one in 1000. Robertsonian translocation is an unusual type of chromosome rearrangement caused by two particular chromosomes joining together. The aim of the study was to analyze the segregation of the ROB translocations in 13 male carriers, and to verify a possible inter-chromosomal effect (ICE) of the ROB t...