The Geological Strength Index (GSI) system, proposed in 1995, is now widely used for the estimation of the rock mass strength and the rock mass deformation parameters. The GSI system concentrates on the description of two factors, rock structure and block surface conditions. The guidelines given by the GSI system are for the estimation of the peak strength parameters of jointed rock masses. The...

In the coal mining process, the destabilization of loaded coal mass is a prerequisite for coal and rock dynamic disaster, and surface cracks of the coal and rock mass are important indicators, reflecting the current state of the coal body. The detection of surface cracks in the coal body plays an important role in coal mine safety monitoring. In this paper, a method for detecting the surface cr...

The serine/threonine kinases ROCK1 and ROCK2 are direct targets of activated rho GTPases, and aberrant rho/ROCK signaling has been implicated in a number of human diseases. We have developed novel methods for high-throughput assays of ROCK inhibitors that provide for quantitative evaluation of the ability of small molecules to inhibit the function of ROCK kinases in intact cells. Conditions for...

In this work, the effect of rock bolt angle on the shear behavior of Rock Bridges is investigated using the particle flow code in two dimensions (PFC2D) for three different Rock Bridge lengths. Firstly, the calibration of PF2D is performed to reproduce the gypsum sample. Then the numerical models with the dimensions of 100 mm * 100 mm are prepared. The Rock Bridge is created in the middle of th...

Objective Contralateral suppression of oto acoustic emission (OAE) is referred as activation of efferent system. Previous literature mentioned about the importance of contralateral suppression of OAEs as a tool to assess efferent system in different groups of population. There is dearth of literature to explore the efferent system function in experienced musicians exposed to rock music using TE...

Glacial reworking of paraglacial rock slope material has been inferred from long-deglaciated terrains to be an important component of glacial sediment transfer. We provide the first description from a contemporary glacial environment of the geomorphological consequences of glacier advance (of the Feegletscher Nord, Switzerland) across a paraglacial rock avalanche deposit. The landform-sediment ...

In this work, the interaction between the semi-circular space and the neighboring joint with and without the presence of rock bolts was investigated using the particle flow code (PFC) approach. For this purpose, firstly, the calibration of PFC was performed using both the Brazilian experimental test and the uniaxial compression test. Secondly, a numerical model with the dimension of 100 m...

The role of the RhoA/Rho kinase (ROCK) signaling pathway in cell survival remains a very controversial issue, with its activation being pro-apoptotic in many cell types and anti-apoptotic in others. To test if ROCK inhibition contributes to tumor cell survival or death following chemotherapy, we treated cisplatin damaged neuroblastoma cells with a pharmacological ROCK inhibitor (Y27632) or sham...

Rock-like materials are composites that can be regarded as a mixture composed of elastic, plastic, and viscous components. They exhibit viscoelastic-plastic behavior under a high-strain-rate loading according to element model theory. This paper presents an analytical solution for stress wave propagation in viscoelastic-plastic rock-like materials under a high-strain-rate loading and verifies th...