this paper addresses the problem of quantifying the mechanical contribution of rockbolts installed systematically around tunnels (regularly spaced around the tunnel) excavated in rock masses. assuming that the mechanical contribution of grouted rockbolts is that of increasing internal pressure within a broken rock mass, a new procedure for computation of ground response curves for a circular tu...

Formation elastic properties near a borehole may be altered from their original state due to the stress concentration around the borehole. This can lead to an incorrect estimation of formation elastic properties measured from sonic logs. Previous work has focused on estimating the elastic properties of the formation surrounding a borehole under anisotropic stress loading. We studied the effect ...

Vascular smooth muscle cells (vSMCs) retain the ability to undergo modulation in their phenotypic continuum, ranging from a mature contractile state to a proliferative, secretory state. vSMC differentiation is modulated by a complex array of microenvironmental cues, which include the biochemical milieu of the cells and the architecture and stiffness of the extracellular matrix. In this study, w...

Being physical mechanical parameters of joints, normal and shear stiffnesses are indispensable components the numerical simulation theoretical analysis behavior joints. The objective this work is to put forward an experimental method determine joint stiffness under constant load (CNL) conditions. For purpose, closure direct tests CNL conditions were conducted. Normal was determined by ratio str...

CD98hc (SLC3A2) is the heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells. Overexpression of CD98hc occurs widely in cancer cells and is associated with poor prognosis clinically, but its exact contributions to tumorigenesis are uncertain. In this study, we showed that genetic deficiency of CD98hc...

Cell mechanical activity generated from the interplay between the extracellular matrix (ECM) and the actin cytoskeleton is essential for the regulation of cell adhesion, spreading and migration during normal and cancer development. Keratins are the intermediate filament (IF) proteins of epithelial cells, expressed as pairs in a lineage/differentiation manner. Hepatic epithelial cell IFs are mad...

CD98hc (SLC3A2) is the heavy chain component of the dimeric transmembrane glycoprotein CD98, which comprises the large neutral amino acid transporter LAT1 (SLC7A5) in cells. Overexpression of CD98hc occurs widely in cancer cells and is associated with poor prognosis clinically, but its exact contributions to tumorigenesis are uncertain. In this study, we showed that genetic deficiency of CD98hc...

In most of the designs of rigid structural frames, the analysis is carried out by assuming fixity at base, which means that the building is idealized to rest on hard rock. This paper discusses the importance of considering the effect of soil stiffness on the seismic performance of rigid structural frame system resting on it. Flexibility of soil causes lengthening of lateral natural period of th...

Multistage constant-amplitude-cyclic (MCAC) loading experiments were conducted on Tibet interbedded skarn to investigate and characterize fatigue mechanical behavior of the tested rock. Rock volumetric deformation, stiffness change, damage evolution analyzed along with macroscopic failure morphology. The experimental results demonstrated that deformation was influenced by interbed structure. pr...