BACKGROUND The effectiveness of sugammadex in reversing rocuronium-induced neuromuscular blockade (NMB) in the presence of drugs that may potentiate NMB remains to be fully established. The aim of this post-hoc analysis of data from a Phase III clinical trial (VISTA; NCT00298831) was to investigate the impact of antibiotics on recovery from rocuronium-induced NMB after administration of sugamma...

OBJECTIVE We aimed to evaluate Visual-Analogue-Scale (VAS) scores, hand-withdrawal, rash and skin eruptions after injections of different concentrations of rocuronium in intubation doses in alert patients using the isolated-forearm technique. METHODS Eighty ASA I-II patients were included in a randomized, controlled, single-blinded study. Two 20 G cannulas were inserted into the dorsum of the...

UNLABELLED We investigated the influence of the timing of neostigmine administration on recovery from rocuronium or vecuronium neuromuscular blockade. Eighty adults and 80 children were randomized to receive 0.45 mg/kg rocuronium or 0.075 mg/kg vecuronium during propofol/fentanyl/N2O anesthesia. Neuromuscular blockade was monitored by train-of-four (TOF) stimulation and adductor pollicis electr...

BACKGROUND AND OBJECTIVES The effects of local anesthetics (LA) on neuromuscular transmission and their influence on the neuromuscular blockade produced by competitive neuromuscular blockers have not been fully investigated. The objective of this study was to evaluate, in vitro, the effects of lidocaine and 50% enantiomeric excess bupivacaine (S75-R25) on the neuromuscular blockade produced by ...

We report here the anesthetic management of a patient with schizophrenia and pseudocholinesterase deficiency. Electroconvulsive therapy was performed using succinylcholine and rocuronium as the neuromuscular blocking agents in the first seven and latter six treatments, respectively. The recovery time from muscle relaxation after succinylcholine administration was remarkably longer than that aft...

BACKGROUND During induction of general anesthesia, the intravenous injection of rocuronium is often associated with withdrawal movement of the arm due to pain, and this abrupt withdrawal may result in dislodgement of the venous catheter, injury, or inadequate injection of rocuronium. We performed this study to evaluate the 50 and 95% effective end-tidal concentrations of sevoflurane (ETsev) for...

1 McDonnell N, Pavy T, Green L, Platt P. Sugammadex in the management of rocuronium-induced anaphylaxis. Br J Anaesth 2011; 106: 199–201 2 Wordsworth H, Raja Y, Harrison S. Sugammadex and rocuronium-induced anaphylaxis. Br J Anaesth 2011; 106: 911–12 3 Rose M, Fisher M. Rocuronium: high risk for anaphylaxis? Br J Anaesth 2001; 86: 678–82 4 Dewachter P, Mouton-Faivre C, Emala C. Anaphylaxis and ...

provided the original work is properly cited. CC Like many other great discoveries, sugammadex was discovered incidentally. Anton Bom, a pharmaceutical chemist employed by Organon, Inc., was attempting to identify a new solvent that could enhance the solubility of rocuronium bromide. Instead, he was the first to discover that long-term use of cyclodextrin as a solubilizing agent offset the pote...

BACKGROUND Intravenous administration of rocuronium bromide causes pain at the site of injection in most patients. The mechanism that leads to this side effect is still unknown and multiple drugs' pretreatments were used to prevent its occurrence with varying success rates. PURPOSE The study aimed to evaluate the effects of the pretreatment with lidocaine, fentanyl, and remifentanil using a v...

BACKGROUND During short surgical procedures and when there is a need to avoid the use of anticholinesterase at the end of surgery, the use of a smaller intubation dose of neuromuscular blocking drug is preferred. The aim of this study was to evaluate tracheal intubation conditions using smaller doses of rocuronium for children under sevoflurane induction. METHODS Eighty American Society of An...