INTRODUCTION Heparin is a widely used anticoagulant that inhibits thrombin and factor Xa via antithrombin III. Bivalirudin is a direct thrombin inhibitor and does not inhibit factor Xa. It inhibits both circulating and clot-bound thrombin. In order to better understand the mechanisms of action of these anticoagulants, we studied their effects on the viscoelastic coagulation tests: Rotational th...

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Methods We conducted an observational, retrospective study in two academic trauma centers from a French university institution. All patients diagnosed with HF on rotational thromboelastometry (ROTEM) between 2010 and 2014 were included. Demographic and clinical parameters, standard laboratory and ROTEM results were collected. HF diagnosis was established when the 60 minute clot lysis index (CLI...

Therapeutic plasma exchange (TPE) is a potentially life-saving procedure which effectively removes donor-specific human leukocyte antigen (HLA) antibodies from the bloodstream, allowing critically ill heart transplant recipients to receive a donor organ with less wait time, and reducing the risk of acute organ rejection. The bulk of coagulation factors is initially removed from the blood during...

Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic method and enables to assess profiles of whole blood in various clinical settings. ROTEM-guided bleeding management has become an essential part patient (PBM) which important concept improving safety. Here, ROTEM testing hemostatic interventions should be linked by evidence-based, setting-specific algorithms adapted the speci...