endometrial adenocarcinoma (ec) usually occurs after menopause, whereas in 2-14% of cases, it occurs in young patients (less than 40 years old) who may desire to keep their fertility. it is of importance to evaluate women for ec when they develop polycystic ovarian syndrome and abnormal uterine bleeding. its treatment includes hysterectomy, bilateral salpingo-oophorectomy and pelvic lymphadenec...

objective: microdeletions of the y chromosome long arm are the most common molecular genetic causes of severe infertility in men. they affect three regions including azoospermia factors (azfa, azfb and azfc), which contain various genes involved in spermatogenesis. the aim of the present study was to reveal the patterns of y chromosome microdeletions in iranian infertile men referred to royan i...

introduction: embryonic stem (es) cells are pluripotent cells derived from inner cell mass of blastocyst. these cells can product any cell by spontaneous or directed differentiation. this study was started to produce neuron cells by directed differentiation of new murine es cell line in vitro. materials and methods: murine es cells (royan b1 derived from c57bl/6 strain) were used for in vitro n...

Purpose To compare the efficacy of two regimens of low dose human chorionic gonadotropin (hCG) on follicular response and oocyte maturation in women with polycystic ovarian syndrome (PCOS). Methods Ninety women with PCOS who underwent assisted reproduction were eligible for this controlled, prospective, randomized study. Our trial was performed at Royan Institute Reproductive Research Center ov...

Introduction: Human embryonic stem cells (hESCs) are pluripotent cells that can proliferate and differentiate to many cell types. Their electrophysiological properties have not yet been chracterzed. In this study, the passive properties (such as resting membrane potential, input resistance and capacitance) and the contribution of delayed rectifier K channel currents to the membrane conductance ...

OBJECTIVE CYP2D6, an enzyme, metabolizes a large number of commonly prescribed drugs. Variations in CYP2D6 gene encoding this enzyme have been associated with individual differences in drug metabolism rates. The purpose of our study was to identify some allelic variants of CYP2D6 gene and to detect defective CYP2D6 alleles, as part of a pharmacogenetic screening program. MATERIALS AND METHODS...

OBJECTIVE To determine the effects of Ramadan fasting on serum levels of stress neurohormones in Iranian women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS This study was a clinical trial and was performed during July 2011 (month of Ramadan) in Royan institute, Tehran. A total of 40 women who were aged 20-40 years and known cases of PCOS and had no other medical diseases were ...

BACKGROUND Supplementation of luteal phase with progesterone is prescribed for women undergoing routine IVF treatment. OBJECTIVE The objective of this study was to compare the efficacy of three types of progesterone on biochemical, clinical and ongoing pregnancy rates and abortion and live birth rates. MATERIALS AND METHODS A prospective randomized study was performed at Royan Institute bet...

OBJECTIVE Due to recent scientific progress in assisted reproductive techniques (ART), infertile couples can now become fertile. Thus, a number of infants in our country are the results of these costly interventions. This study has been undertaken to evaluate the physical growth process of different methods of ART infants by standard growth charts from birth until nine months of age. METHODS ...