We conducted a case-control study to evaluate the association of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) polymorphisms with the risk of hepatocellular carcinoma. A total of 274 patients with HCC were collected between January 2013 and December 2014. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...

Here, we carried out an investigation of the relationship between miR-146a (rs2910164), miR-149 (rs2292832), miR-196a2 (rs11614913) and miR-499 (rs3746444) polymorphisms and development of ovarian cancer in a Chinese population. With a hospital-based case-control design, 155 patients and 342 control subjects were involved in the First Affiliated Hospital of Harbin Medical University between Mar...

We aimed to investigate the correlation between the four common single nucleotide polymorphisms (SNPs) in microRNAs (miR146a rs2910164, miR-196a2 rs11614913, miR-499 rs3746444 and miR-149 rs2292832) and hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) risk through a systematic review and meta-analysis. Odds ratios (ORs) along with 95% confidence intervals (95% CIs) were pool...

microRNAs (miRNA) are a new class of non-protein-coding, small RNAs that function as tumor suppressors or oncogenes. They participate in diverse biological pathways and function as gene regulators. Recently, we conducted a survey of common single nucleotide polymorphisms (SNP) in miRNA sequences and reported that, among four SNPs (rs2910164, rs2292832, rs11614913, and rs3746444) in pre-miRNAs, ...

OBJECTIVE Functional single nucleotide polymorphisms (SNPs) of microRNA (miRNA) sequences or binding sites (miRNA-SNPs) are associated with lung cancer risk and survival. The objective of this study was to systematically review genetic association studies about miRNA-SNPs in lung cancer. METHODS Eligible genetic association studies were retrieved from databases of PubMed, EMBASE, China Nation...

BACKGROUND Micro RNAs (miRNAs) are small RNA fragments that naturally exist in the human body. Through various physiological mechanisms, miRNAs can generate different functions for regulating RNA protein levels and balancing abnormalities. Abnormal miRNA expression has been reported to be highly related to several diseases and cancers. Single-nucleotide polymorphisms (SNPs) in miRNAs have been ...

Objective(s): Accumulating evidence has demonstrated that miRNAs contribute to various genetic and epigenetic modifications in the pathogenesis of gastric cancer (GC). Recent studies focused on the four single nucleotide polymorphisms (SNPs) of pre-miRNAs including rs11614913, rs3746444, rs2910164, and rs2292832. It was suggested that these four SNPs were significantly associated with the risk ...

Background: Two single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, miR-149 C>T (rs2292832) and miR-499 A>G (rs3746444), may be associated with risk of hepatocellular carcinoma (HCC), but the results remain controversial. Available evidence was meta-analyzed to assess the potential association. Methods: PubMed/Medline, Embase, Web of Science, the Cochrane Library, CBM databases, a...