We developed a useful method for the detection of rubella virus genome RNA by reverse transcription loop-mediated isothermal amplification (RT-LAMP) and compared the sensitivity of RT-LAMP with that of other virological tests: reverse transcription-PCR (RT-PCR) and virus isolation. The rubella virus genome was amplified by RT-LAMP from clinical isolates obtained between 1987 and 2004 with simil...

Although a major section of pregnant women in Nigeria are immune to rubella infection, cases of congenital rubella syndrome are still been seen in hospitals. Rubella is not a reportable disease in Nigeria and data of its epidemiology are extremely rare. In this study, we estimate the burden of acute rubella virus infection among pregnant women during their first trimester in Makurdi-Benue State...

There is growing evidence for the role of rubella virus in Fuchs' uveitis syndrome (FUS). This report is the first to show persistent intraocular rubella virus in a 28-year-old man with congenital rubella syndrome (CRS), who presented with blurred vision and was diagnosed with FUS.

background rubella is a viral disease with a worldwide distribution. mass vaccination campaigns have increased the vaccine coverage in the world with substantial impact on reduction of rubella infections. in iran, the national measles-rubella campaign, targeting individuals 5-25 years old, was initiated in 2003 and mass childhood vaccination against measles, rubella and mumps has continued ever...

BACKGROUND Development of congenital rubella syndrome associated with rubella virus infection during pregnancy is clinically important, but the pathogenicity of the virus remains unclear. METHODS Pathological examination was conducted on 3 aborted fetuses with congenital rubella infection. FINDINGS At autopsy, all 3 aborted fetuses showed congenital cataract confirmed by gross observation. ...

We recently described a new precipitating antigen, rho, in the blood of patients with rubella infection, and in the fluids from rubella virus-infected cell cultures (1). The antigen was detected by gel diffusion using antisera from rabbits which had been hyperimmunized with fractions of purified rubella virus. Although, on the basis of these and other preliminary experiments it seemed likely th...

Rubella virus infection is typically diagnosed by the identification of rubella virus-specific immunoglobulin M (IgM) antibodies in serum, but approximately 50% of serum samples from rubella cases collected on the day of rash onset are negative for rubella virus-specific IgM. The ability to detect IgM in sera and oral fluids was compared with the ability to detect rubella virus RNA in oral flui...

The teratogenic effect of rubella virus in humans has now been well documented (Ingalls, Plotkin, Meyer & Parkman, 1967) and virus isolation studies have suggested that rubella virus causes embryopathy by actually infecting the cells of the developing foetus (Alford, Neva & Weller, 1964). However, a laboratory animal model is required for controlled studies of the teratogenic activity of rubell...

BACKGROUND The seroepidemiology of rubella virus infection in pregnant women in northern Mexico is largely unknown. We sought to determine the seroprevalence of rubella virus infection in pregnant women in the northern Mexican city of Durango, Mexico. Seroprevalence association with the socio-demographic, clinical and behavioral characteristics of the pregnant women was also investigated. MET...

measles, rubella, mumps, hepatitis b virus (hbv) and varicella zoster virus (vzv) cause infectious diseases that can be effectively prevented by vaccination. vaccination of medical students is important, because they are more likely to become exposed and infected by these viruses. a total of 180 students, consisting of 90 women and 90 men, were serologically screened for measles, rubella and mu...