results the results of this study showed some s. pneumoniae serotypes were found in both sexes and some only in one sex invasive infections. for example, serotypes 10, 14, 18 and 22 were only in female patients with infections. conclusions the analysis of the results had suggested that serotypes 6 from lung and 19 from eye are the most abundant bacterial strains isolated from patients. the dise...

Macrolide resistant Streptococcus pneumoniae has been increasing rapidly in Southeast Asia. A review from 2000 through 2011 at Charoenkrung Pracharak Hospital that evaluated drug resistance to erythromycin found S. pneumoniae from 158 of the 390 (40.5%) patients: 3.6% intermediate, 36.9% highly resistant. A significant correlation was found between macrolide resistant S. pneumoniae and penicill...

objective: in-time diagnosis of streptococcus pneumoniae (s. pneumonia) can play a significant role in decreasing morbidity and mortality rate. applying molecular methods has gained popularity due to the existing limits of routine diagnostic methods. examining the expression of different genes of this bacterium through different molecular methods suggests that lyta gene has a higher sensitivity...

Patients with multiple myeloma (MM) are at an increased risk for infections with bacteria that require opsonization with complement. Because Streptococcus pneumoniae is the most frequently encountered pathogen in these patients, we investigated the ability of serum from patients with MM to mediate the binding of C3b, the major opsonin of the complement system, to S. pneumoniae. S. pneumoniae ty...

Streptococcus (S.) pneumoniae is the most common causative pathogen in community-acquired pneumonia. Nucleotide-binding oligomerization domain-containing (NOD) 2 is a pattern recognition receptor located in the cytosol of myeloid cells that is able to detect peptidoglycan fragments of S. pneumoniae. We here aimed to investigate the role of NOD2 in the host response during pneumococcal pneumonia...

Streptococcus pneumoniae is second only to Mycobacterium tuberculosis as a bacterial cause of worldwide mortality. Unlike M tuberculosis, S pneumoniae remains a major cause of death in the developed world, with a standardised mortality rate of 25 per 100 000 in the UK. S pneumoniae is the commonest pathogen causing community acquired pneumonia (CAP), and the majority of serious S pneumoniae inf...

Recovery of Streptococcus pneumoniae from positive blood culture bottles may be difficult due to autolysis of pneumococci. Therefore, we evaluated the performance of the Binax NOW S. pneumoniae antigen test with samples from positive blood culture bottles and defined the duration of detectable pneumococcal antigen in these bottles. Use of the S. pneumoniae antigen test is an alternative method ...

The antibacterial susceptibility to frequently prescribed antibiotics of Streptococcus pneumoniae isolated from the pediatric patients with acute respiratory infectious diseases was investigated in a study of three medical institutions in Korea. Total 143 clinical isolates of S. pneumoniae were available for susceptibility tests between May 2003 and July 2007. Antimicrobial susceptibility data ...

Streptococcus pneumoniae fructose bisphosphate aldolase (FBA) is a cell wall-localized lectin. We demonstrate that recombinant (r) FBA and anti-rFBA antibodies inhibit encapsulated and unencapsulated S. pneumoniae serotype 3 adherence to A549 type II lung carcinoma epithelial cells. A random combinatorial peptide library expressed by filamentous phage was screened with rFBA. Eleven of 30 rFBA-b...

Streptococcus pneumoniae (S. pneumoniae) is the important pathogen that causes otolaryngeal diseases such as sinusitis. S. pneumoniae frequently forms the biofilm to prevent severe circumstances such as antimicrobial agents. Shin'iseihaito (xinyiqingfeitang) is a formula of Japanese traditional Kampo medicine that has 9 crude drugs and provides the medicinal usage for sinusitis. The objective o...