IntroductionTreatment of infected non-unions the tibia is a challenging problem. The cornerstones optimal non-union treatment consist extensive debridement, fracture fixation, antimicrobial therapy and creation an local biological bone healing environment. combination S53P4 bioactive glass (BAG), as osteostimulative antibacterial graft substitute, marrow aspirate concentrate (BMAC) for implanta...

Aim: To evaluate the efficacy of bioglass (BAG-S53P4) in the treatment of patients with chronic osteomyelitis and compare the results with calcium sulphate antibiotic beads in one medical centre. Methods: Retrospective analysis of 25 cases. INCLUSION CRITERIA patients diagnosed clinically and radiographically of osteomyelitis and treated surgically (Group 1: cavitary bone defects treated with...

The effects of bioactive glass S53P4 or beta-tricalcium phosphate; and bone morphogenetic proteins bone morphogenetic protein-2, bone morphogenetic protein-7, or bone morphogenetic protein-2 + 7 on osteogenic differentiation of human adipose stem cells were compared in control medium, osteogenic medium, and bone morphogenetic protein-supplemented osteogenic medium to assess suitability for bone...

BACKGROUND A novel, bioactive, fiber-reinforced composite implant is a solution to address the shortcomings in craniofacial bone reconstruction. A longitudinal clinical investigation with a follow-up time of 4 years was conducted. METHODS A cranial bone reconstruction with the implant was performed on 12 patients. In these patients, the reasons for craniotomies resulting in craniofacial bone ...

OBJECTIVES Chronic infection of the middle ear and cholesteatoma can be treated surgically by exenteration of the mastoid air cells behind the ear. After a procedure with the canal wall-down technique, a cavity remains that is sometimes difficult to clean, collects crust, and becomes repeatedly infected. Such problematic mastoid cavities can be eliminated by filling the created cavity surgicall...

Synthetic biomaterials mimicking bone morphology have expanded at a tremendous rate. Among all, one stands out: bioactive glass. Bioactive glasses opened the door to a new genre of research into materials able to promote the regeneration of functioning bone tissue. However, despite their ability to promote cell attachment, proliferation and differentiation, these materials are mainly used as gr...

In this study, the fabrication and properties of a synthetic keratoprosthesis skirt for use in osteo-odonto-keratoprosthesis (OOKP) surgery are discussed. In the search for a new material concept, bioactive glass and polymethyl methacrylate (PMMA)-based composites were prepared. Three different bioactive glasses (i.e. 45S5, S53P4 and 1-98) and one slowly resorbing glass, FL107, with two differe...

Bioactive glasses (BGs) are promising for bone tissue regeneration. BG composition can be tailored, according to the application of interest, and/or functionalized with organic molecules/biomolecules improve their performances. However, despite wide knowledge concerning BGs, interaction proteins, fundamental controlling fate implant, has not been deeply investigated yet. Controlling or predicti...