Very few studies describe the fate of artificial sweeteners (ASWs) in wastewater treatment plants (WWTPs). In this study, mass loadings, removal efficiencies, and environmental emission of sucralose, saccharin, aspartame, and acesulfame were determined based on the concentrations measured in wastewater influent, primary effluent, effluent, suspended particulate matter (SPM), and sludge collecte...

GOSNELL, B. A. AND C. K. PATEL. Centrally administered Itand &opioid agonists increase operant responding for saccharin. PHARMACOL BIOCHEM BEHAV 45(4) 979-982, 1993.--In previous reports, ICV administration of selective Itor 8-opioid receptor agonists was found to stimulate the intake of saccharin and salt solutions in nondepdved rats. In the present study, we measured the effects of selective ...

The results of recent studies suggest that the mouse Sac (saccharin preference) locus is identical to the Tas1r3 (taste receptor) gene. The goal of this study was to identify Tas1r3 sequence variants associated with saccharin preference in a large number of inbred mouse strains. Initially, we sequenced approximately 6.7 kb of the Tas1r3 gene and its flanking regions from six inbred mouse strain...

Experiment 1 sought to determine whether schedule-induced drinking could be abolished by means of a taste aversion. Polydipsic rats were given access to a .4% saccharin solution while they were exposed to an intermittent food schedule. Immediately after the session, they received an intraperitoneal injection of either lithium chloride or sodium chloride. Following a recovery day with water in t...

A series of studies examined the (Sprague-Dawley) rat's tendency to suppress intake of .15% saccharin when it was followed by a second food after 4-, 16-, or 32-min delays. The second foods examined were 32% sucrose, 64% sucrose, lab chow, a Nutrasweet solution, skim milk, and chocolate milk. Saccharin intake was influenced by both the delay and the specific food available. Subsequent analysis ...

Foraging behavior is an expression of learning, context, and experience arising from integration of sensory information obtained during feeding with postingestive consequences of food ingestion. Although it has been well established that gustatory and olfactory systems of the mouth and nose provide sensory information to the consumer (in the form of flavor), sweet and bitter taste receptors hav...

Introduction Saccharin was found to induce bladder tumours in male rats of the first and the second generation after life-long feeding of a diet containing 5% saccharin [1]. On the other band, with lower doses, and in epidemiological sturlies on the human consumption as sweetening agent there is no clear evidence for a carcinogenic activity despite the long and widespread use [ 2] . This contro...

In three experiments, water-deprived rats were preexposed to a novel saccharin solution. The neophobic response to this flavor was then assessed in a choice test involving saccharin and water, administered either immediately or 24 h after preexposure. Subjects displayed a significantly greater preference for saccharin at the 24-h test than at the immediate test (Experiments 2 and 3).This "incub...

This study examined the relationship between saccharin drinking, open field behaviour and ethanol drinking in Wistar rats. Correlational analysis revealed that both absolute saccharin drinking and an increase in total fluid intake in the presence of saccharin positively correlated with the initial acceptance of increasing ethanol concentrations in a two-bottle choice situation (2-8% v/v ethanol...