PURPOSE Although extraocular muscle (EOM) is skeletal muscle, aspects of its biology are unlike other striated muscle. In this study, the broad molecular genetics profile underlying the novel EOM phenotype was examined. METHODS Serial analysis of gene expression (SAGE) was used to quantify adult rat EOM gene transcripts. SAGE isolates and sequences 10-bp tags from defined locations in mRNA-de...

The antioxidant properties of sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.), their mixtures were examined using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH•) scavenging activity ferric-reducing plasma (FRAP) methods. antimicrobial plant extracts against four bacterial strains (Escherichia coli, Staphylococcus aureus, Bacillus cereus, Salmonella typhomorium) was determined agar well di...

Colorectal cancer (CRC) is a common malignancy and significant cause of mortality in Western societies. It develops through an accumulation of genetic and epigenetic alterations, transforming normal colon cells and giving them growth advantage. Epigenetic alterations are reversible and studies have shown that dietary compounds can alter the epigenetic status and reactivate epigenetically-silenc...

Hyperlipidemia is a common metabolic disorder contributing to morbidities and mortalities due to cardiovascular and cerebrovascular diseases. Conventional antihyperlipidemic drugs have limited efficacies and important side effects, so that alternative lipid lowering agents are needed. Salvia officinalis L. (sage) leaves have PPAR γ agonistic, pancreatic lipase and lipid absorption inhibitory, a...

Common sage (Salvia officinalis L.) is among the plants that are claimed to be beneficial to diabetic patients, and previous studies have suggested that some of its extracts have hypoglycaemic effects in normal and diabetic animals. In the present study, we aimed to verify the antidiabetic effects of an infusion (tea) of common sage, which is the most common form of this plant consumed. Replaci...

This study presents an attempt to evaluate the antioxidant potential and antimicrobial activity of methanolic extract, and essential oils prepared from the leaves of sage (Salvia officinalis L.). The content of polyphenol in the methanolic extracts from the leaves of Salvia officinalis was determined spectrophotometrically, calculated as gallic acid and catechin equivalent. The essential oils a...

The analysis of differentially expressed genes is a powerful approach to elucidate the genetic mechanisms underlying the morphological and evolutionary diversity among serially homologous structures, both within the same organism (e.g., hand vs. foot) and between different species (e.g., hand vs. wing). In the developing embryo, limb-specific expression of Pitx1, Tbx4, and Tbx5 regulates the de...

AIM The aims of this study were to evaluate the effects of intramammary infusion of sage (Salvia officinalis) essential oil (EO) on milk somatic cell count (SCC), milk composition parameters and selected hematology and serum biochemical parameters in 20 Awassi ewes affected with subclinical mastitis. MATERIALS AND METHODS The dried leaves of sage were used to extract the EO by hydrodistillati...