Sodium salicylate was administered to anesthetized dogs in doses sufficient to produce concentrations in plasma comparable to those common in human salicylate toxicity. Salicylate administration increased the rates of excretion of water, sodium, and chloride in the urine. Salicylate administration also increased the rate of excretion of potassium so that its clearance often exceeded that of cre...

Although several workers have observed that the bacteriostatic effect of salicylate can be reversed by pantothenate, there is disagreement about the reaction step affected. Salicylate has been considered to inhibit synthesis of pantoate (Ivanovics, 1942), the conversion of pantoate to pantothenate (Roblin, 1949), and the utilization of pantothenate (Mcllwain, 1943; Work and Work, 1948); Ackeima...

Salicylate, the active ingredient of aspirin can cause sensorineural hearing loss and tinnitus when plasma concentrations reach a critical level. The ototoxic mechanisms of salicylate remain unclear but hearing and tinnitus usually recovers a few days after intoxication. There have been few reports of salicylate-induced ototoxicity in Korea, and the majority is caused by a low dose of aspirin. ...

Salicylate's ototoxic properties have been well established, inducing tinnitus and a sensory hearing loss when administered in high doses. Peripherally, acute dosing of salicylate causes frequency dependent reductions in DPOAEs and CAP amplitudes in low (<10 kHz) and high (>20 kHz) frequencies more than mid frequencies (10-20 kHz), which interestingly corresponds to the pitch of behaviourally-m...

Salicylate, one of the most widely used drugs, is known to induce reversible tinnitus and hearing loss. Salicylate interferes with outer hair cells (OHCs), which are believed to underlie normal auditory frequency selectivity and sensitivity. In the present experiments, the effects of salicylate and lanthanides on OHC motility and nonlinear capacitance were investigated by using isolated guinea-...

A flavoprotein, salicylate hydroxylase (salicylate, DPNH : oxygen oxidoreductase (I -hydroxylation, l-decarboxylating)), has been induced and isolated from a soil bacterium grown on salicylate as sole carbon source. In contrast to a similar enzyme studied by YAMAMOTO, S., KATAGIRI, M., MAENO, H., AND HAYAISHI, 0. ((1965) J. Bid, Chem. 240, 3408) this enzyme is dimeric with two subunits and two ...

The physiological role of NahW, the second salicylate hydroxylase of Pseudomonas stutzeri AN10, has been analysed by gene mutation and further complementation. When grown on naphthalene as a unique carbon and energy source, the nahW mutant showed a strong decrease in salicylate hydroxylase activity when compared with the wild-type strain, exhibited lower specific growth rates and accumulated sa...

The purpose of this investigation was to determine the effect of ultrasound intensity and mode on serum salicylate levels following phonophoresis. Approximately 12-13 g of a salicylate product (Myoflex) was applied to the right anterior forearm of five males and two females. Randomly ordered ultrasound treatment intensities (0.0 W.cm-2; 1.5 W.cm-2, pulsed 50%; and 1.5 W.cm-2, continuous) were a...

Salicylate induces multiple antibiotic resistance in various bacterial species. Here we investigated the effect of salicylate on the susceptibility of Mycobacterium tuberculosis to a range of antituberculosis (anti-TB) drugs. In the presence of salicylate, the killing effects of isoniazid (INH), rifampin (RMP), ethambutol (EMB), streptomycin (STR), and p-aminosalicylate (PAS) were reduced, as s...