Vasopressin antagonists increase the serum sodium concentration in patients who have euvolemia and hypervolemia with hyponatremia in the short term (</=30 days), but their safety and efficacy with longer term administration is unknown. SALTWATER was a multicenter, open-label extension of the Study of Ascending Levels of Tolvaptan in Hyponatremia (SALT-1 and SALT-2). In total, 111 patients with ...

[1] The mixing zone between freshwater and seawater in a coastal aquifer is an important transition region that controls regional groundwater flow dynamics and reactive transport processes. While experimental procedures have been developed to study the movement of salt wedges in aquifers, so far no one has attempted to exclusivelymap themixing zone associated with the wedge in a laboratory-scal...

Contemporary sea-level rise will inundate coastal habitats with seawater more frequently, disrupting the life cycles of terrestrial fauna well before permanent habitat loss occurs. Sea turtles are reliant on low-lying coastal habitats worldwide for nesting, where eggs buried in the sand remain vulnerable to inundation until hatching. We show that saltwater inundation directly lowers the viabili...

Two experiments were conducted to determine the effects of a mild or severe stressor on the saltwater preference of juvenile spring chinook salmon (Oncorhynchus tshawytscha). To observe the response of fish to an overhead threat, we presented stressed fish with an avian predator model in the second experiment. Experiments were conducted in 757-L tanks containing a stable vertical salinity gradi...

Maintenance of genetic variation at loci under selection has profound implications for adaptation under environmental change. In temporally and spatially varying habitats, non-neutral polymorphism could be maintained by heterozygote advantage across environments (marginal overdominance), which could be greatly increased by beneficial reversal of dominance across conditions. We tested for revers...

In this paper, we consider the flow of fresh and saltwater in a saturated porous medium in order to describe the seawater intrusion. Starting from a formulation with constant densities respectively of fresh and saltwater, whose velocities are proportional to the gradient of pressure (Darcy’s law), we consider the formal asymptotic limit as the aspect ratio between the thickness and the horizont...

In this paper, we consider the flow of fresh and saltwater in a saturated porous medium in order to describe the seawater intrusion. Starting from a formulation with constant densities respectively of fresh and of saltwater, whose velocity is proportional to the gradient of pressure (Darcy’s law), we consider the formal asymptotic shallow water limit as the ratio between the thickness and the h...

Saline water intrusion into freshwater aquifers is a major geohydraulic problem relevant to coastal environment. Apart from contaminating the fresh groundwater resources, saltwater alters geotechnical properties of aquifer materials, affecting resource planning and management. The present study focuses on an in-depth laboratory investigation influence submergence sand. fine sand sample was subm...