Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory disease, which has now been classified as a seronegative spondyloarthritis. The sternoclavicular and sternocostal joints, pelvis, vertebra, hip, and long bones are affected. Skin findings of the disease are accepted as a variant of pustular psoriasis, but some authors have suggested that palmoplantar pustulosis (PPP) is a different...

Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is a rare disorder characterized by osteoarticular and dermatological manifestations. The denotation was first proposed by Chamot et al. in 1987 after investigation of 85 cases (Chamot et al., 1987). The most common site of SAPHO syndrome is the upper anterior chest wall, characterized by predominantly osteosclerotic lesions and h...

INTRODUCTION Angiogenesis is involved in the pathogenesis of arthritis. OBJECTIVES The aim of the study was to assess the serum levels of selected angiogenic cytokines and their association with clinical presentation in patients with psoriatic arthritis (PsA) and SAPHO syndrome. PATIENTS AND METHODS We studied 98 patients: 80 with PsA and 18 with SAPHO syndrome. The following data were reco...

les figures mythiques ou légendaires s’adaptent à chaque époque et en chaque lieu. cet article tente de montrer comment constance pipelet, future princesse de salm (1767-1845), une des filles des lumières et admiratrice des idéaux de la révolution française, se sert du récit de la vie de sapho, grande poétesse de l’antiquité, pour proposer une sapho qui est aussi amoureuse, éplorée et trahie qu...

The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism (1). SAPHO syndrome is a rare disease, characterized by specific clinical manifestations of synovitis, acne pustulosis, hyperostosis, and osteitis. It is a disease that manifests with a combination of osseous and articular manifestations ...

INTRODUCTION The acronym SAPHO was introduced in 1987 to unify the various descriptions of a seronegative arthritis associated with skin manifestations and to show synovitis, acne, pustulosis, hyperostosis, and osteitis with and without sterile multifocal osteomyelitis. The etiology of SAPHO syndrome is unknown, but an association with infection by semipathogenic bacteria like Propionibacterium...

Results We followed seven patients diagnosed as CRMO, 6 female and 1 male. Bone pain was the leading symptom; median age of first complaint was 11 years (range 8-14 ys). The majority of bone lesions were located in the metaphyses of the long bones (10 sites, 63%), clavicle (3 sites, 19%) and pelvis (2 sites, 12%). Five patients had more than one lesion at onset. Of the latter, one patient remai...

Chronic mandibular osteomyelitis is an intractable disease. In recent years, some case reports have related this disease process to synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, which is chronic with frequent remissions and exacerbations. This report describes a case of chronic mandibular osteomyelitis suspected to be SAPHO syndrome. A 68-year-old woman presented wit...

INTRODUCTION The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteomyelitis) is a rare painful disorder, usually with a good long-term prognosis. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. CASE PRESENTATION A 46-year-old Caucasian female was referred for anterior chest wall and back pain. Physical examination was unremark...

BACKGROUND In recent years the SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) has been encountered more frequently. However, clinical evidence indicating superiority of a specific therapeutic modality is still absent. Pamidronate, a second-generation bisphosphonate, has a pronounced effect on bone metabolism by suppressing bone resorption. We report our clinical experie...