Abstract Excess glutamate in the central nervous system may be a major cause of neurodegenerative diseases with gradual loss and dysfunction neurons. Primary or secondary metabolites from medicinal plants algae show potential for treatment glutamate-induced excitotoxicity. Three plant extracts were evaluated impact on excitotoxicity-induced primary cultures retinal ganglion cells (RGC). These t...


 Red flour beetle, Tribolium castaneum Herbst (Coleoptera: Tenebrionidae) is one of the major insect pests stored grains. Due to export legislation and zero-tolerance for live insects in trade commodities, extensive use synthetic insecticides practice eliminate pest infestations from lots. Currently, only acceptable chemical be used grain phosphine but due its excessive usage, are becomin...

Plant-based remedies have been widely used for the management of variable diseases due to their safety and less side effects. In present study, we investigated Saussurea lappa CB. Clarke. (SL) given its largely reported medicinal Specifically, our objective was provide an insight into a new polymethyl methacrylate based nanocapsules as carriers SL essential oil characterize biologic functions. ...

The effects of aqueous-methanol extract of Saussurea lappa Clarke root (Sl.Cr) was investigated against D-galactosamine (D-GalN) and lipopolysaccharide (LPS)-induced hepatitis in mice. Co-administration of D-GalN (700 mg/kg) and LPS (1 microg/kg) significantly raised the plasma transaminase levels (ALT/AST) as compared to the control group (p < 0.05). Pretreatment of mice with different doses o...

Ionizing radiation is known to induce multiple organ dysfunctions directly related to an increase of cellular oxidative stress, due to overproduction of reactive oxygen species (ROS). This study was aimed to investigate the effect of septilin (an ayurvedic poly-herbal formulation containing the principal herbs, namely Commiphora wightii, Trinospora cordifolia, Rubia cardifolia, Emblica officina...

Saussurea lappa Clarke (SLC) has been used as a traditional medicine in Korea, China, and Japan for the treatment of abdominal pain and tenesmus. Costunolide, a sesquiterpene lactone isolated from SLC, has diverse medicinal effects. However, the anticancer effects of costunolide are still unclear in breast cancer. In this study, we demonstrate that costunolide suppresses tumor growth and metast...