The formation of disulphide bridges among cysteines is an important feature of protein structures. Here we develop new methods for the prediction of disulphide bond connectivity. We first build a large curated data set of proteins containing disulphide bridges and then use 2-Dimensional Recursive Neural Networks to predict bonding probabilities between cysteine pairs. These probabilities in tur...

Many analytics applications generate mixed workloads, i.e., workloads comprised of analytical tasks with different processing characteristics including data pre-processing, SQL, and iterative machine learning algorithms. Examples of such mixed workloads can be found in web data analysis, social media analysis, and graph analytics, where they are executed repetitively on large input datasets (e....

Kernel machines such as kernel SVM and kernel ridge regression usually construct high quality models; however, their use in real-world applications remains limited due to the high prediction cost. In this paper, we present two novel insights for improving the prediction efficiency of kernel machines. First, we show that by adding “pseudo landmark points” to the classical Nyström kernel approxim...