OBJECTIVE To examine pulmonary function, dyspnea and exercise capacity in adult Saudi sickle cell disease (SCD) patients. METHODS The patients were recruited from the hematology clinic at King Khalid University Hospital in Riyadh from January to December 2005. The study involved 39 patients with stable SCD (20 women and 19 men), with a mean age of 22.7+/-7.1 years, hemoglobin level of 95.5+/-...

BACKGROUND Non-invasive prenatal diagnosis (NIPD) for sickle-cell disorder (SCD) is moving closer to implementation and studies considering stakeholder preferences are required to underpin strategies for offering NIPD in clinical practice. OBJECTIVE Determine service user and provider preferences for key attributes of prenatal diagnostic tests for SCD and examine views on NIPD. METHOD A que...

Patients with sickle cell disease (SCD) are more susceptible to severe coronavirus 2019 (COVID‑19) infection, in comparison the general population, due possibility that inflammatory state, along hypoxia and hypercoagulability may increase risk of developing acute SCD‑related complications. The present study reports case a 33‑year‑old female affected by SCD, who although vaccinated against COVID...

Background and Objectives Bacterial infection in sickle cell anaemic patients is a major cause of mortality and requires proper treatment with appropriate antibiotics. However, continue defiant of these infections causing pathogens to many antibiotics and inadequate screening methods in overburden health care facilities such as our in Kano, Nigeria necessitates the conduct of this study. A rese...

Persistence of human fetal hemoglobin (HbF, α(2)γ(2)) in adults lessens the severity of sickle cell disease (SCD) and the β-thalassemias. Here, we show that the repressor BCL11A is required in vivo for silencing of γ-globin expression in adult animals, yet dispensable for red cell production. BCL11A serves as a barrier to HbF reactivation by known HbF inducing agents. In a proof-of-principle te...

Prior research has identified a number of areas of cognitive deficit among children with sickle cell disease (SCD), including decrements in memory span and working memory. The present study examined short-term memory span and working memory performance among children with SCD (n = 25) and demographically matched comparison children (n = 25) using digit span, spatial span, and the self-ordered p...

BACKGROUND Diabetes predisposes to sudden cardiac death (SCD). However, it is uncertain whether greater proportion of cardiac deaths are sudden among diabetes patients than other subjects. It is also unclear whether the risk of SCD is pronounced already early in the course of the disease. The relationship of impaired glucose tolerance (IGT) and SCD is scarcely documented. METHODS A general po...

This article summarizes the psychometric evaluation of the Chronic Illness Assessment Interview for Sickle Cell Disease (CIAI-SCD), an instrument based on a model of self-care for adult patients with chronic medical conditions. The CIAI-SCD was administered to 104 adults with sickle cell disease. A factor analysis identified three factors that reflected the psychological constructs of Personal ...

1. Introduction minimum required predictive accuracy of the test will vary amongst physicians. As there is no consensus on the The prediction of sudden arrhythmic death (SCD) in criteria for ICD implantation, we hope to achieve a patients with non-coronary heart disease has become positive predictive accuracy (PPA) of 0.3 so that three out increasingly important because of the need to select hi...

Despite widespread advances in coronary heart disease (CHD) treatment and the growing use of implantable cardioverter-defibrillators (ICDs), sudden cardiac death (SCD) remains a major cause of CHD death in the United States,1 and identification of patients at risk for SCD remains a challenge. Left ventricular ejection fraction (LVEF) has been found to be the strongest independent predictor of S...