Gene knockout mice studies indicate that urokinase-type plasminogen activator (u-PA) is importantly involved in fibrinolysis, but its physiologic mechanism of action remains poorly understood. We postulated that platelets may be involved in this mechanism, as they carry a novel receptor for u-PA and a portion of the single-chain u-PA (scu-PA) intrinsic to blood is tightly associated with platel...

BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by excessive fat accumulation in the form of triglycerides. The incidence of NAFLD and hyperlipidemia, with their associated risks of end-stage liver and cardiovascular diseases, is increasing rapidly. This study aimed to investigate the effects of scutellarin on the experimental NAFLD in high-fat diet fed and chro...

Thrombomodulin (TM), a membrane proteoglycan on endothelial cells, binds thrombin in a 1:1 complex, accelerates the protein C activation by thrombin, promotes the thrombin inactivation by antithrombin III and inhibits the procoagulant properties of thrombin. The inactivation of single-chain urokinase-type plasminogen activator (scu-PA) by thrombin is accelerated about 70-fold by TM [De Munk, Gr...

ObjectiveThroughout Europe, the number of older adults requiring acute hospitalization is increasing. Admission to an geriatric unit outside a general hospital could be alternative. In this model medical care, comprehensive assessment and rehabilitation are provided selected patients. This study aims compare patients' diagnoses, characteristics, outcomes 2 European sites where care occurs.Desig...

BACKGROUND Diabetic retinopathy is the most common complication in diabetic patients relates to high expression of VEGF and microaneurysms. Scutellarin (Scu) turned out to be effective against diabetes related vascular endothelial cell dysfunction. However, its clinical applications have been limited by its low bioavailability. In this study, we formulated and characterized a novel intestinal t...

BACKGROUND AND PURPOSE Geographically distinct multidisciplinary stroke care units (SCUs) have been shown by systematic reviews to have superior patient outcomes compared with conventional care in general medical wards. However, the effectiveness of SCUs in smaller North American community hospitals is less well defined. The objective of this study was to determine the impact of establishing a ...

nitrogen use efficiency (nue) is usually lower in paddy rice (oryza sativa l.) than in upland crops. for this reason, any attempt to improve nue through the use of different nitrogen (n) carriers, different rice cultivars, properly timed n application, the use of ni-trification and urease inhibitorsis of prime interest. moreover, zinc (zn) next to n seems to be the most important soil factor af...

In the FAIR control system the SCU (Scalable Control Unit, an industry PC with a bus system for interfacing electronics) is the standard front-end controller for power supplies. The FESA-framework is used to implement front-end software in a standardized way, to give the user a unified look on the installed equipment. As we were dealing with different power converters and thus with different SC...

The effect of pH on Cu(I) and Cu(II) forms of the isolated soluble domain of the stellacyanin from Rhus vernicifera (SCu), the Japanese lacquer tree, has been studied by electronic and NMR spectroscopy and using direct electrochemical measurements. A pK(a) value of 10.1-10.4 is observed for the alkaline transition in this oxidized phytocyanin and results in a slightly altered active-site struct...