Pioneering epidemiological work has established strong association of sedentary lifestyle and obesity with the risk of colorectal cancer, while the detailed underlying mechanism remains unknown. Here we show that Hotair (HOX transcript antisense RNA) is a pro-adipogenic long non-coding RNA highly expressed in gluteal-femoral fat over other fat depots. Hotair knockout in adipose tissue results i...

BACKGROUND The American "stroke belt" has contributed to the study of stroke. However, U.S. geographic patterns of diabetes have not been as specifically characterized. PURPOSE This study identifies a geographically coherent region of the U.S. where the prevalence of diagnosed diabetes is especially high, called the "diabetes belt." METHODS In 2010, data from the 2007 and 2008 Behavioral Ri...

OBJECTIVE To determine the association between family structure, maternal education level, and maternal employment with sedentary lifestyle in primary school-age children. METHOD Data were obtained from 897 children aged 6 to 12 years. A questionnaire was used to collect information. Body mass index (BMI) was determined using the age- and gender-specific Centers for Disease Control and Preven...

OBJECTIVE To assess risk factors for chronic noncommunicable disease (CND) and to identity social inequalities in their distribution among the adult Brazilian population. METHODS Study of CND risk factors (including tobacco use, overweight and obesity, low fruit and vegetable intake (LFVI), insufficient leisure-time physical activity (LTPA), sedentary lifestyle, and alcohol abuse, among other...

Sedentary lifestyle is highly associated with increased risk of cardiovascular disease, obesity, and type 2 diabetes. It is known that regular physical activity has positive effects on health; however several studies have shown that acute and strenuous exercise can induce oxidative stress and lead to DNA damage. As magnesium is essential in maintaining DNA integrity, the aim of this study was t...

BACKGROUND Smoking, sedentary lifestyle and obesity are risk factors for mortality and dementia. However, their impact on cognitive impairment-free life expectancy (CIFLE)has not previously been estimated. METHODS Data were drawn from the DYNOPTA dataset which was derived by harmonizing and pooling common measures from five longitudinal ageing studies. Participants for whom the Mini-Mental St...

BACKGROUND Project ACTIVE was a randomized clinical trial comparing two physical activity interventions, lifestyle and traditional structured exercise. The two interventions were evaluated and compared in terms of cost effectiveness and ability to enhance physical activity among sedentary adults. DESIGN This was a randomized clinical trial. SETTING/ PARTICIPANTS The study included 235 seden...

The role of mitochondrial dysfunction and oxidative stress has been extensively characterized in the aetiology of sarcopenia (aging-associated loss of muscle mass) and muscle wasting as a result of muscle disuse. What remains less clear is whether the decline in skeletal muscle mitochondrial oxidative capacity is purely a function of the aging process or if the sedentary lifestyle of older adul...

120 Corresponding author: Jorge Mota: Faculty of Sport, University of Porto, Rua Dr. Plácido Costa, 91, 4200-450 Porto, Portugal • Tel: 00351225074785 • Fax: 00351225500689 • Email: [email protected] Copyright ©2012 CIAFEL. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are fre...

OBJECTIVE This study evaluates whether a sedentary lifestyle is an independent predictor for increased mortality after elective cardiac surgery. METHODS Three thousand one hundred fifty patients undergoing elective cardiac surgery between January 2007 and June 2012 completed preoperatively the Corpus Christi Heart Project questionnaire concerning physical activity (PA). Based on this question...