PURPOSE Vagus nerve stimulation (VNS) is a neurophysiologic treatment for patients with refractory epilepsy. There is growing evidence of additional quality of life (QOL) benefits of VNS. We report the effects of VNS on seizure frequency and severity and how these changes are related to cognitive abilities, QOL, behaviour and mood in 15 children with medically refractory and for surgery not eli...

We investigated the relationship between CT findings - number and the viability phase of the parasites - and the seizure frequency in children with neurocysticercosis before and short-term after antiepileptic drug (AED) introduction. We only found a significant interaction between stage of parasitic infection and number of lesions on seizure frequency after AED treatment. Patients with more tha...

objective febrile seizure is the most common problem in pediatric neurology that occurs in 3- 4 % of children. the purpose of this study was to determine febrile seizure recurrence frequency and to evaluate its risk factors. materials & methods in a descriptive prospective study, 139 children (6 months to 6 years) with first febrile seizure were admitted to yazd shaheed sadoughi hospital betwee...

how to cite this article: taghdiri mm, bakhshandeh bali mk, karimzadeh p, ashrafi mr, tonekaboni sh, ghofrani m. comparative efficacy of zonisamide and pregabalin as an adjunctive therapy in children with refractory epilepsy. iran j child neurol. 2015 winter;9(1):49-55. abstract objective approximately one third of epileptic children are resistant to anticonvulsant drugs. this study evaluates t...

OBJECTIVES The ability to analyze patterns of recorded seizure activity is important in the localization and classification of seizures. Ictal evolution is typically a dynamic process with signals composed of multiple frequencies; this can limit or complicate methods of analysis. The recently-developed matching pursuit algorithm permits continuous time-frequency analyses, making it particularly...

We have previously reported that dogs can be trained to recognize specific changes preceding an epileptic seizure in humans. Such dogs can provide an overt signal that acts as a useful warning to the human. Early observations suggested that seizure frequency might also be reduced. We report a prospective study of 10 consecutive referrals to our Seizure Alert Dogs service of people with tonic-cl...

Background There is currently no formal method for predicting the range expected in an individual's seizure counts. Having access to such a prediction would be of benefit for developing more efficient clinical trials, but also for improving clinical care in the outpatient setting. Methods Using three independently collected patient diary datasets, we explored the predictability of seizure fre...

In this paper, we present a new method based on empirical mode decomposition (EMD) for classification of seizure and seizure-free EEG signals. The EMD method decomposes the EEG signal into a set of narrow-band amplitude and frequency modulated (AM-FM) components known as intrinsic mode functions (IMFs). The method proposes the use of the area parameter and mean frequency estimation of IMFs in t...