The aim of this research was to investigate the Cyclooxygenase-2 (COX-2) selective inhibition effect on haloperidol-induced catatonia. In this study, the effect of orally, acutely and Sub-chronically administrations of compound 11b [1-(phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole] (2, 4 and 8 mg/kg), a newly selective COX-2 inhibitor, was investigated against the haloperidol-induced ...

Cancer is considered as a challenging deathly disease and discovering or synthesis of new cytotoxic agents is a worldwide attempt. In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having differesnt COX-1 and/or COX-2 selectivities, have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7...

Cancer is considered as a challenging deathly disease and discovering or synthesis of new cytotoxic agents is a worldwide attempt. In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having differesnt COX-1 and/or COX-2 selectivities, have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7...

Introduction: Ketoprofen is an NSAID and selective COX-1 inhibitor. In our previous study the role of flunixin meglumine, a nonselective COX inhibitor was studied on seizure and its anticonvulsant effects were confirmed. Therefore this research is performed to assess the role of a selective COX-1 inhibitor, ketoprofen in treatment of seizures induced by PTZ. Methods: In this research, male ...

Evidence shows that suboptimal adherence to gastroprotective agents (GPAs) decreases the beneficial effects on the risk of upper gastrointestinal (GI) complications (UGIC) associated with the use of traditional non steroidal anti-inflammatory drugs (NSAIDs) [1]. There is less evidence about the role of GPA adherence for lowering the risk of UGIC in selective cyclooxygenase (COX)-2 inhibitors us...

UNLABELLED BACKGROUND AND SUMMARY: Selective cyclooxygenase (COX)-2 inhibitors are increasingly being used in place of "conventional" nonsteroidal anti-inflammatory drugs (NSAIDs). This is because they are just as effective as NSAIDs in relieving arthritic pain and yet less gastrotoxic. However, the cardiovascular safety of selective COX-2 inhibitors has been questioned because they selectively...

Sickness behavior appears to be the expression of a central motivational state that reorganizes the organism’s priorities to cope with infectious pathogens.To evaluate the effect of selective and non selective COX inhibitors in lipopolysaccharides induced sickness behaviour,rats were subjected to the forced swim test (FST), open field test,actophotometer. LPS(10mcg/kg i.p). administration incre...

Adenocarcinoma in Barrett’s esophagus has been increasing in incidence at a rapid rate for more than two decades. Cyclooxygenase (COX)-2 appears to play an important role in gastrointestinal carcinogenesis, and COX-2 overexpression has been demonstrated both in esophageal adenocarcinomas and in the metaplastic epithelium of Barrett’s esophagus. The aim of our study was to determine whether sele...

Nonsteroidal anti-inflammatory drugs (NSAIDs) act mainly via inhibition of prostaglandins synthesis by inhibition of cyclooxygenase (COX) isoenzymes (COX1 and COX 2). Selective COX-2 inhibitors which are also known as coxibs provide the main therapeutic effects of NSAIDs. Zarghi et al. reported 6-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid (AZGH 101) as a novel derivative of...

Adenocarcinoma in Barrett's esophagus has been increasing in incidence at a rapid rate for more than two decades. Cyclooxygenase (COX)-2 appears to play an important role in gastrointestinal carcinogenesis, and COX-2 overexpression has been demonstrated both in esophageal adenocarcinomas and in the metaplastic epithelium of Barrett's esophagus. The aim of our study was to determine whether sele...