Adenosine receptors (ARs) are potential therapeutic targets for Parkinson's disease, diabetes, pain, stroke and cancers. Prediction of subtype selectivity is therefore important from both therapeutic and mechanistic perspectives. In this paper, we introduced a shape similarity profile as molecular descriptor, namely three-dimensional biologically relevant spectrum (BRS-3D), for AR selectivity p...

An attempt has been made to develop a highly selective Cu2+-ion selective electrode based on a poly(vinyl chloride) based sensor using 1,2,5,6,8,11-hexaazacyclododeca-7,12-dione-2,4,8,10-tetraene as ionophore with 61.5% DBP in the presence of 29% PVC, 4.5% ionophore and 5% NaTBP as an anion excluder. The sensor exhibits a near Nernstian potential response of 29.5 +/- 0.3 mV per decade over a wi...

This paper describes the implementation of biorthogonal cosine-modulated filter banks on fixed-point arithmetic digital signal processors. The proposed implementation has the property that the overall filter bank keeps the perfect reconstruction property despite coefficient quantization, overflow, and rounding of intermediate results. The realization of the prototype filter is based on a factor...

Ca(2+)-selective microelectrodes with Simon's neutral carrier ETH 1001 are commercially available and have been widely used for the measurement of both extra- and intracellular calcium. The electrodes demonstrate high selectivity against other cations such as magnesium, sodium, and potassium. We report, however, that the ETH 1001-based microelectrode is a superior tetraphenylphosphonium (TPP+)-...

The objective of this work is to provide a tool for the electrochemical detection and quantification of dopamine in biological environments in the presence of ascorbic and uric acids (AA, UA). Sonogel electrodes modified with L-Cysteine prepared in this work showed very remarkable electrochemical performance for the determination of dopamine; the results obtained show good selectivity and sensi...

Properties of the room-temperature liquid complex salt [Ag(propene)(x)][Tf(2)N] have been studied to probe its suitability for acting as active separation layer in immobilised liquid membrane (ILM) concepts for propane/propene separation. The pressure/temperature range of complex formation has been determined and the thermal properties of Ag[Tf(2)N] and [Ag(propene)(x)][Tf(2)N] have been studie...

The coordination polymers [Ag4 (O2 CCF3 )4 (phen)3 ]⋅ phen⋅arene (1⋅phen⋅arene) (phen=phenazine; arene=toluene, p-xylene or benzene) have been synthesised from the solution phase in a series of arene solvents and crystallographically characterised. By contrast, analogous syntheses from o-xylene and m-xylene as the solvent yield the solvent-free coordination polymer [Ag4 (O2 CCF3 )4 (phen)2 ] (2...

Kaolinite supported bimetallic Pt-Sn catalysts were prepared via impregnation technique using different solvents, water, ethanol and acetone. The catalysts were characterized by X-ray diffraction pattern and temperature programmed reduction techniques. Surface area and pore size distribution were determined by nitrogen physisorption technique. The activities of the catalysts were measured towar...

Facilitated transport through polymer inclusion membranes (PIMs) is a promising method for simultaneous separation and removal of valuable and toxic metal ions from aqueous solutions. Recently, ionic liquids (ILs) have been used as extracting agents for metal ions due to their unique physicochemical properties. This paper presents research on the facilitated transport of cadmium(II) and copper(...