Aim of the present investigation was to develop the Self Microemulsifying Drug Delivery System (SMEDDS) of Furosemide. Furosemide is Class IV molecule according to BCS (Biopharmaceutical Classification System), having low solubility and low permeability. Prepared optimized SMEDDS of Furosemide composed of CAPTEX 500 as oil and Cremophore EL as surfactant in 20:80 ratio. Optimized SMEDDS of Furo...

The present work was aimed at formulating a SMEDDS (Self-microemulsifying drug delivery system) for oral drug delivery system containing flutamide. The solubility of flutamide was determined in various vehicles. Pseudo ternary phase diagram was constructed to identify the micro emulsification existence area. SMEDDS formulations were tested for microemulsifying properties, and the resultant form...

In recent years there has been increasing attention given to the utility of selfmicroemulsifying systems (SMES) for improving the gastrointestinal absorption of drugs with inadequate biopharmaceutical properties. Microencapsulation of those systems into polymeric matrix is one of the solidification techniques that allow formulation of solid self-microemulsifing formulations. Microcapsules with ...

A colon-specific capsule with alginate beads containing a self-microemulsifying drug delivery system (SMEDDS) was developed and evaluated. The SMEDDS technique was used to improve the solubility of curcumin (Cur). After encapsulating the Cur-loaded SMEDDS, the alginate beads were placed inside an impermeable capsule body. A konjac glucomannan/lactose/hydroxypropyl methylcellulose (KG/Lac/ HPMC)...