The design and synthesis of a family of cationic, pH-sensitive poly(amidoamine)s are reported. Acetal or ketal linkages were incorporated into the backbone of the polymers to provide for degradation into low molecular weight hydrophilic compounds upon lowering of the pH. All of the polymers demonstrated a pHdependent degradation profile with a very significant increase in hydrolysis rate as the...

Objective(s): The aim of present research was to develop matrix-mini-tablets of lornoxicam filled in capsule for targeting early morning peak symptoms of rheumatoid arthritis. Materials and Methods:Matrix-mini-tablets of lornoxicam were prepared by direct compression method using microsomal enzyme dependent and pH-sensitive polymers which were further filled into an empty HPMC capsule. To asses...

This review deals with the targeting of drugs to the lower gastrointestinal tract i.e. colon. Colonic drug delivery becomes important for localized action as well as for improved systemic availability of peptide and proteins. Drugs which have absorption window in the colonic region have been targeted using different novel technologies. pH sensitive polymers and prodrug based formulation have be...

Polymers that respond to small changes in environmental stimuli with large, sometimes discontinuous changes in their physical state or properties are often called "intelligent" or "smart" polymers. We have conjugated these polymers to different recognition proteins, including antibodies, protein A, streptavidin, and enzymes. These bioconjugates have been prepared by random polymer conjugation t...

Monodisperse water-soluble Co and gamma-Fe(2)O(3) nanoparticles have been prepared in a single-step method using stimuli-sensitive polymers.

The weak fluorescence of lanthanide/nucleotide coordination polymers was greatly enhanced by Ag(+) in aqueous solution, which has been used for highly sensitive sensing of Ag(+).

A simple and extremely sensitive dual-amplification platform for the detection of DNA was developed combining signal amplification of conjugated polymers and recyclable autocatalytic hybridization of DNA.

The effects of silicates upon erythrocytes depend upon the degree of polymerization. Monomeric silicate does not appear to be taken up by red cells. Polymerized silicates are taken up and bound tightly. In the presence of small polymeric forms erythrocytes are lysed by complement. Larger polymers are bound to erythrocytes but do not sensitize to complement hemolysis. Larger polymers, however, a...