Calcium/calmodulin kinase II (CaMKII) is required for LTP and experience-dependent potentiation in the barrel cortex. Here, we find that whisker deprivation increases LTP in the layer IV to II/III pathway and that PKA antagonists block the additional LTP. No LTP was seen in undeprived CaMKII-T286A mice, but whisker deprivation again unmasked PKA-sensitive LTP. Infusion of a PKA agonist potentia...

p , ROLONGED SPACE travel by man may require severe social restrictions, and stringent conditions of sensory and perceptual impoverishment. These conditions of space travel are similar to phenomena generally investigated in studies of sensory deprivation. Studies in sensory deprivation have indicated many detrimental effects in performance due to impoverished sensory environment. 23, 25 It has ...

Sensory cortices undergo crossmodal reorganisation as a consequence of sensory deprivation. Congenital deafness in humans represents a particular case with respect to other types of sensory deprivation, because cortical reorganisation is not only a consequence of auditory deprivation, but also of language-driven mechanisms. Visual crossmodal plasticity has been found in secondary auditory corti...

Neurophysiological mapping was used to study the effects of early postnatal removal of mystacial whiskers on the organization of cutaneous receptive fields (RFs) within the ventral posterior thalamus (VP) of rats. This sensory deprivation induced an extensive reorganization of the thalamus, as reflected in larger facial or continuous overlapping face-body RFs and a higher proportion of slowly-a...

Herpes simplex viruses (HSV1 and HSV2) establish latency in peripheral ganglia after ocular or genital infection, and can reactivate to produce different patterns and frequencies of recurrent disease. Previous studies showed that nerve growth factor (NGF) maintains HSV1 latency in embryonic sympathetic and sensory neurons. However, adult sensory neurons are no longer dependent on NGF for surviv...

Experience-dependent maturation of neocortical circuits is required for normal sensory and cognitive abilities, which are distorted in neurodevelopmental disorders. We tested whether experience-dependent neocortical modifications require Ube3a, an E3 ubiquitin ligase whose dysregulation has been implicated in autism and Angelman syndrome. Using visual cortex as a model, we found that experience...

Postnatal bilateral whisker trimming was used as a model system to test how synaptic proteomes are altered in barrel cortex by sensory deprivation during synaptogenesis. Using quantitative mass spectrometry, we quantified more than 7,000 synaptic proteins and identified 89 significantly reduced and 161 significantly elevated proteins in sensory-deprived synapses, 22 of which were validated by i...

The effects of sensory deprivation on excitatory and inhibitory activity in the primary somatosensory cortex were studied in the adult rat. Excitatory and inhibitory transmission generated by whisker stimulation, and neuronal responsiveness to iontophoretically applied excitatory amino acids were recorded. Whisker input deprivation, through whisker trimming for a median of 24 days, resulted in ...

Early loss of one sensory system can cause improved function of other sensory systems. However, both the time course and neuronal mechanism of cross-modal plasticity remain elusive. Recent study using functional MRI in humans suggests a role of the prefrontal cortex (PFC) in cross-modal plasticity. Since this phenomenon is assumed to be associated with altered GABAergic inhibition in the PFC, w...