The pathogenesis of the sepsis syndrome is critically dependent on activation of the innate immune response. Innate immunity plays a direct role in the development of sepsis and is also crucial for the activation and modulation of later antigen-specifi c adaptive immune responses. Nearly all of the clinical manifestations of sepsis and the systemic infl ammatory response syndrome (SIRS) can be ...

CRITICALCARENURSE Vol 26, No. 3, JUNE 2006 43 sion of the bloodstream by micro organisms. However, a subset of critically ill patients have features characteristic of sepsis despite blood cultures that are repeatedly negative for microorganisms and no identified source of bacterial, fungal, or viral infection. Trauma, surgery, burns, and illnesses such as cancer and pneumonia can trigger the on...

Sepsis is complex syndrome with endothelial barrier integrity compromise, contributing to end-organ dysfunction. Some findings have established that markers of septic endothelial activation are associated with extent of sepsis severity, organ dysfunction and mortality. Endocan is a novel endothelium derived soluble dermatan sulfate proteoglycan and endocan’s increased serum levels founded in pa...

Sepsis and its related syndromes represent potentially devastating illnesses, estimated to account for 1% of all hospital admissions and for 100 000 deaths per annum in the U.S.A. alone. Although sepsis is defined as the systemic response to infection, an infective organism is found in fewer than 50% of cases. It is therefore increasingly recognised that sepsis represents only one example of a ...

abstract objective: to assess the incidence of thrombocytopenia and changes in various platelet parameters, in culture positive neonatal sepsis. methods: this was prospective study conducted over a period of one year from december 2009 to november 2010 in neonatal intensive care unit of dduh hospital, a tertiary care hospital in delhi, north india. all babies who were admitted during this perio...

Introduction Sepsis is a syndrome of systemic inflammation arising from infection that constitutes a top-ten cause of adult mortality. The recent withdrawal of a specific sepsis therapeutic has diminished pharmaceutical enthusiasm for developing novel drugs in this domain. Angiopoietin-2 (Angpt-2) is an endothelial-derived protein that potentiates vascular inflammation and permeability and may ...

BACKGROUND Systemic inflammatory response syndrome (SIRS) is a clinical syndrome following inflammation. Clinically, it is difficult to distinguish SIRS following an infection, i.e., sepsis, from non-infectious SIRS. Myeloperoxidase is a hemeprotein stored in the neutrophil azurophilic granules and is one of the main pillars of neutrophil attack. Therefore, we hypothesized that myeloperoxidase ...

This article outlines the causes, signs and symptoms of systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and septic shock, the implications and available treatments. The article also highlights a campaign to reduce the incidence of sepsis and reflects on efforts to reduce healthcare-associated infections.

Sepsis is a common clinical syndrome characterized by infection accompanied by systemic inflammation. The systemic inflammation (systemic inflammatory response syndrome – SIRS), which may be also related to non-infectious causes (Fig. 1), manifests itself as changes in temperature (>38oC or <36oC), tachycardia (>90 per minute), tachypnea (>20 per minute), or changes in white blood cell count in...

BACKGROUND A large amount of research demonstrates the importance of key interventions in reducing mortality rates of pediatric patients with sepsis (Dellinger et al., 2008). Assessment and recognition of declining status must occur for interventions to be initiated. Of health care practitioners, nurses typically spend the most time with patients, and they must be knowledgeable in recognizing t...