Hitherto a standard conservative approach has been to deny operation to all applicants with mild or minimal deformities, since it is claimed that they must necessarily have severe underlying psychiatric problems and therefore operation must inevitably prove disastrous. Another symptom might be substituted, the patient is likely to become dissatisfied and possibly litigious, and a florid psychos...

Periventricular leukomalacia (PVL) is well recognized as a relatively uncommon yet particularly serious complication of prematurity. Although the sonographic features of PVL have been described, its association with intraventricular hemorrhage (IVH) has not been emphasized. Reviewing 26 consecutive cases of PVL in neonates of 34 weeks or less gestational age, significant associated hemorrhage w...

• Diagnostic measures to determine the existence and exact location of established or propagating thrombi would be of obvious clinical significance. The use of a gammaemitting isotope attached to a compound which would concentrate in such lesions could provide a diagnostic technique with the advantages of rapidity, portability, safety, and simplicity. Several investigators have studied the fate...

In a paper from the Dutch group long-term consequences of tympanostomy tube treatment is reported. Three hundred fifty-eight subjects with a positive and negative history of OM or tympanostomy tube insertion derived from a birth cohort had been followed-up from preschool to adult age. TM abnormalities were investigated at ages of 8 and 18 years. The occurrence of myringosclerosis was 6 times as...

Cerebral malaria (CM) in children is associated with a high mortality and long-term neurocognitive sequelae. Both erythropoietin (Epo) and vascular endothelial growth factor (VEGF) have been shown to be neuroprotective. We hypothesized that high plasma and cerebrospinal fluid (CSF) levels of these cytokines would prevent neurological sequelae in children with CM. We measured Epo, VEGF, and tumo...

To quantify the risk and types of sequelae attributable to prior enteric infections, we undertook a population-based retrospective cohort study using linked administrative records. The risk for first-time hospitalization for sequelae was modeled by using Cox proportional regression analysis controlling for other health and sociodemographic factors. We identified a significant increase of 64% in...