The syndrome of inappropriate antidiuretic hormone secretion has only been reported in a few patients with large cell neuroendocrine carcinoma (LCNEC); however, it has never been reported in a patient with LCNEC of the lung, whose serum sodium levels were normalized after surgical resection of the mass. A 63-year-old male presented with a two-day history of dizziness and recent memory loss. On ...

In 1938 Wolfram reported the occurrence of diabetes mellitus and optic atrophy in four of eight sibs.' Over 100 similar cases have since been reported and several other clinical features have been described.2 3,4 The genetic disorder is commonly known as DIDMOAD syndrome, the mnemonic for Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness. This report describes three siblings wit...

An animal model was designed to study the effect of large volume Hypertonic Solutions (HTS) for re‌suscitation following a hypovolemic shock. Resuscitation in hypovolemic animals was performed by infusion of 15 ml/kg of normal saline (group I), 5% sodium bicarbonate (NaHCO3) (group II), 5% sodium chloride (NaCI) and 7.5 % NaHCO3 1:1 VN (group III), 5% NaC1 (group IV), and 5% NaCl and 5% serum a...

Hyperhosphatemia and secondary hyperparathyroidism are common and severe complications of chronic renal failure. Therapies to reduce serum phosphate have been shown to reduce serum parathyroid hormone (PTH) and slow the progression of renal failure. The effect of the inhibitor of intestinal phosphate absorption, 2'-phosphophloretin (2'-PP), on serum and urine chemistry, renal histology, and car...

Plasma sodium and osmolality were determined in 80 adult epileptic patients receiving chronic treatment with carbamazepine and in 50 control patients treated with other anticonvulsant drugs. Mean plasma osmolality was significantly lower in the carbamazepine-treated patients but mean plasma sodium did not differ in the two groups. Hyponatraemia was found in five of the carbamazine-treated patie...

Osmotic activity is the process when water in one solution, with lower concentration of e.g. salt ions or sugar molecules, moves through a semipermeable barrier in the direction of a higher concentration to equalize concentrations. The osmotic activity could both be measured in milliosmoles/kilogram (mOsm/kg) solvent, i.e. osmolality, and calculated as milliosmoles/liter (mOsm/L) solution, i.e....

Standard methods for behavioral and neurophysiological experiments in the non-human primate rely on controlled water access as a means for motivating subject performance. It is, however, still not clear whether animals are able to regulate their fluid balance appropriately under these experimental settings. Further, the physical state associated with a subject monkey's thirst has not yet been o...

The effect of colchicine, Nocodazole or vinblastine on the movement of mouse bone marrow neutrophils was examined by the method of migration under agarose. Migration was estimated by counts of the numbers of cells that left the wells and moved under the gel. Micromolar concentrations of the agents increased spontaneous migration 2- to 4-fold, while lumicolchicine was ineffective. The increase m...

Serum osmolality and serum inorganic ion concentrations were studied in two antarctic fish species, Trematomus bernacchii and T. newnesi, during 5 weeks of acclimation to 4 degrees C and compared with control values for groups acclimated to -1.5 degrees C. Acclimation to 4 degrees C significantly decreased the serum osmolality of both species, thereby increasing their seawater-to-extracellular ...