Psoriasis vulgaris is an immune-mediated inflammatory skin disease. Although acitretin is a widely used synthetic retinoid for moderate to severe psoriasis, little is known about patients' genetics in response to this drug. In this study, 179 patients were enrolled in either the discovery set (13 patients) or replication set (166 patients). The discovery set was sequenced by whole exome sequenc...

With more than 1.4 billion overweight or obese adults worldwide, obesity and progression of the metabolic syndrome are major health and economic challenges. To address mechanisms of obesity, adipose tissue-derived mesenchymal stem cells (ADSCs) are being studied to detail the molecular mechanisms involved in adipogenic differentiation. Activation of the Wnt signalling pathway has inhibited adip...

Background: Identification of breast cancer stem cells as the chemo-resistant and tumor-initiating population represents an important milestone in approaching anticancer therapies. Targeting this minor subpopulation of chemo- and radio-resistant stem-like cells, termed as the cancer stem cells (CSCs) and their eradication could significantly enhance clinical outcomes. Most of the presently admi...

Hidradenitis suppurativa(HS) is a chronic skin disease characterized by massive immune cell infiltrate, tissue destruction and extensive fibrosis. We aimed to elucidate the role of fibroblasts(FBs) in pathophysiology HS. performed single RNA-seq on lesional 5 HS patients 7 controls.Ex vivo experiments were primary dermal FBs from lesions (n=5). FB subclustering revealed 6 subsets; SFRP2+, COL11...