The authors investigated risk profiles of sudden infant death syndrome (SIDS) as a function of age at death. A case-control study carried out in the Tyrol region of Austria enrolled 99 infants who died of SIDS between 1984 and 1994 and 136 randomly selected controls. Early and late SIDS (< 120 days of age vs. > or = 120 days) were defined according to the clear-cut bimodal age-at-death distribu...

The association between Long QT syndrome (LQTS) and sudden infant death syndrome (SIDS) remains highly topical and even polarizing. Because the landmark Italian study of the QT interval and SIDS triggered extensive controversy, there has been a substantial and commendable effort to establish LQTS as one of the true causes of SIDS. The motivation underlying this effort is based on the fact that ...

UNLABELLED Despite the large reduction in SIDS mortality, which occurred in the early 1990s following the 'Back to Sleep' campaigns, SIDS remains the leading cause of death in the postneonatal age group. This paper describes the position in the 1980s, the contribution of the New Zealand Cot Death Study, what should be recommended and the current research priorities. CONCLUSION SIDS is prevent...

This study was designed to assess whether development of the central nervous system (CNS) is delayed in victims of the sudden infant death syndrome (SIDS). We selected the parameter of myelination because it is a continuously changing and readily accessible marker of CNS development in the SIDS age-range. We assessed myelination blindly in 61 SIDS and 89 autopsy controls. In 62 sites the degree...

STUDY OBJECTIVE To examine and identify relations between sudden infant death syndrome (SIDS) and wind, particularly the föhn wind, in Christchurch, New Zealand. DESIGN A retrospective epidemiological study combining details of regional hourly meteorological variables and reported SIDS cases. SETTING Christchurch, New Zealand, between 1968 and 1997 inclusively. PARTICIPANTS All 646 infant...

Small island developing states (SIDS) are among the most vulnerable countries to impacts of coronavirus (COVID-19) crisis, which is disrupting key economic sectors that SIDS’ undiversified and already fragile economies strongly rely upon. While they succeeding contain health emergency, SIDS faced with severe require bold government action adequate international support. This policy brief: (i) h...

Sudden infant death syndrome (SIDS) is the leading cause of death in infants between the ages of 1 and 12 months in developed countries. SIDS is by definition a diagnosis of exclusion, and its mechanism of action is unknown. The SIDS-Critical Diaphragm Failure (CDF) hypothesis postulates that the cause of death in SIDS is respiratory failure caused by CDF. Four principal risk factors contribute...

STUDY OBJECTIVE To examine and identify relationships between the sudden infant death syndrome (SIDS) and environmental temperature in Canterbury, New Zealand. DESIGN A retrospective epidemiological study combining details of regional hourly temperature and reported SIDS cases. SETTING Canterbury, New Zealand, between 1968 and 1989 inclusively. PARTICIPANTS All infants reported as dying f...

Immunoreactive expression of three cell death markers was quantitatively analysed in the human infant brainstem medulla. We assessed active caspase-3, TUNEL and single-stranded DNA (ssDNA) in a cohort of 92 infants, and analysed for: (i) variations in the immunoreactive expression with development; (ii) comparison of infants diagnosed with the Sudden Infant Death Syndrome (SIDS, n = 67) to infa...

BACKGROUND Twins compared to singletons are at increased risk of sudden infant death syndrome (SIDS). AIMS To compare the epidemiology of SIDS in twins and singletons and to test the hypothesis that monozygous (MZ) were at greater risk of SIDS than dizygous (DZ) twins. METHODS Data from the Office for National Statistics on all registered live births and infant deaths with registered cause ...