Improving prediction of the skin permeability coefficient is a difficult problem, and an important issue with the increasing use of skin patches as a means of drug delivery. In this work, we apply Gaussian Processes (GPs) with five different covariance functions to predict the permeability coefficients of human, pig, rodent and silastic membranes. We obtain a considerable improvement over quant...

The effect of a new long-acting caldum antagonist. Amlodipine, on experimental vasospasm was tested using arat femoral artery vasospasm model and morphometry, Twenty-four rats were divided into 3 groups, In group i. the femoral arteries were removed aft:er cardiac perfusion, In groups 2 and 3, the right and [overed with a silastic cuf!". In these groups the left femoral arteries were covered wi...

The use of animal models, especially the rat, is crucial for elucidating the biological effects and mechanisms of the widely used hormone 17beta-oestradiol. Unfortunately, there is a lack of consensus on optimal means of obtaining and maintaining physiological 17beta-oestradiol concentrations in plasma and this may be the reason for the varying results in several studies, including the disagree...

BACKGROUND AND PURPOSE Unilateral vocal cord paralysis (UVCP) occurs after iatrogenic injury or disease process and is associated with dysphonia and aspiration. Various surgical options are available for treatment of UVCP, including vocal cord medialization thyroplasty and injection laryngoplasty. These augmentative procedures improve phonation and airway protection. Our purpose was to demonstr...