The aim of the present study was to investigate the effect of sildenafil citrate (viagra) on retinal venous diameter in patients with age-related macular degeneration (AMD). We investigated 14 male patients in a double-masked, randomized, placebo-controlled, crossover study. In each subject, one eye with typical non-exudative AMD fundus features was studied. Each of the subjects received 100 mg...

OBJECTIVES An acceleration of the wound healing process expedites chronic wound patient's return to normal social environments significantly. Sildenafil, a cyclic guanosine monophosphate (cGMP)-dependent phosphodiesterase- 5 inhibitor has been shown to be a potent stimulator of angiogenesis through upregulation of cGMP. In our study, sildenafil was administered orally as a cost-effective supple...

The present study deals with the effects of sildenafil citrate (Viagra) on the nocturnal sleep related erectile dysfunctions in diabetic neuropathic men. In this investigation 50 type 1 and 50 type 2 diabetic patients with and without an objective evidence of neuropathy, aged between 15 to 60 years with a duration of diabetes distributed over 1-20 years were included along with their age matche...

OBJECTIVE The objective of this study is to develop and characterize in situ thermosensitive gels for the vaginal administration of sildenafil as a potential treatment of endometrial thinning occurring as a result of using clomiphene citrate for ovulation induction in women with type II eugonadotrophic anovulation. While sildenafil has shown promising results in the treatment of infertility in ...

 Background & Objective:  Sildenafil citrate is a potential new strategy for the management of intrauterine growth restriction (IUGR) and preeclampsia, although its efficacy still needs to be approved. Accordingly, the aim of this study was to systematically assess the effectiveness of sildenafil on improving fetal Doppler indices, as well as the most common adverse effects of sildenafil.  ...

KIROGLU, A.F., BAYRAKLI, H., YUCA, K., CANKAYA, H. and KIRIS, M. Nasal Obstruction as a Common Side-Effect of Sildenafil Citrate. Tohoku J. Exp. Med., 2006, 208 (3), 251-254 ── Sildenafil citrate is an effective oral drug for erectile dysfunction. The main action of sildenafil is the enhancement of the effect of nitric oxide (NO) by inhibiting the cyclic guanosine monophosphate (cGMP)-specific ...

PURPOSE To our knowledge we report the first large, randomized, prospective penile rehabilitation clinical trial to compare the effectiveness of nightly intraurethral alprostadil vs sildenafil citrate after nerve sparing prostatectomy. MATERIALS AND METHODS We performed a prospective, randomized, open label, multicenter American study in men with normal erectile function who underwent bilater...

Two simple, accurate, sensitive and reproducible methods have been developed and subsequent validated for the determination of Sildenafil citrate (SC) in presence of its impurities “1-methyl-4-nitro-3-n-propyl-5pyrozole Carboxamide (MNC), 4-amino-1-methyl-3-n-propyl-5-pyrazole Carboxamide (AMP), 4-(2-ethoxy benzoyl amino)-1-methyl-3-n-propyl-5-pyrazole Carboxamide (EMC) and 5-(2-ethoxyphenyl)-1...

OBJECTIVES To evaluate the long-term effect and safety of sildenafil citrate for the treatment of erectile dysfunction after radical prostatectomy (RP). METHODS The study consisted of 91 patients with erectile dysfunction from our institution who received oral sildenafil citrate after RP. We surveyed these patients using a self-administered questionnaire during the first year of sildenafil ci...

Sildenafil citrate (Viagra) is the most widely used pharmacological drug for treating erectile dysfunction in men. It has potent cardioprotective effects against ischemia-reperfusion injury via nitric oxide and opening of mitochondrial ATP-sensitive K(+) channels. We further investigated the role of protein kinase C (PKC)-dependent signaling pathway in sildenafil-induced cardioprotection. Rabbi...