Surgical site infections (SSI) are a known complication of surgery. Silver-containing wound treatments are popular, despite the lack of evidence of SSI reduction. A two-armed study was conducted between July 2007 and November 2008 to evaluate the efficacy and ease of use of a postoperative silver dressing. In the first arm of the study, patients undergoing clean general, vascular, orthopedic, a...

BACKGROUND Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs). AIM To evaluate ulcer healing through a meta-analytic approach af...

OBJECTIVE To establish whether honey and silver-impregnated dressings used by wound-healing practitioners are cytotoxic in vitro to human skin keratinocytes and dermal fibroblasts. METHOD Human keratinocyte and fibroblast tissue cultures were established in vitro. Untreated cultures served as controls (group I). Small dressing implants of monofloral, medicinal honey (L-Mesitran) (group 2) and...

Silver nanoparticles are gaining importance as an antimicrobial agent in wound dressings. Chitin is a biopolymer envisioned to promote rapid dermal regeneration and accelerate wound healing. This study was focused on the evaluation of chitin membranes containing silver nanoparticles for use as an antimicrobial wound dressing. Silver nanoparticles were synthesised by gamma irradiation at doses o...

Bacterial colonisation of wounds may delay wound healing. Modern silver-containing dressings are antimicrobial, yet cellular toxicity is a serious side-effect. We provide data for a newly formulated silver-containing ointment dressing, Atrauman Ag, for antimicrobial activity and cytotoxicity. Atrauman Ag effectively killed a panel of commensal skin as well as pathogenic bacterial strains while ...

Aims: To investigate the physical and antimicrobial properties of low-adherent, silver-containing gelling fibre and certain adhesive foam dressings in vitro. Methods: An in vitro model was used to quantitatively measure fibroblast adhesion to dressings in their dry and hydrated states. Microscopy techniques were used to visualise and quantify aspects of dressing composition and structure. Final...

silver sulfadiazine is used to prevent and treat infections of second- and third-degree burns. it kills a wide variety of bacteria. in this study silver sulfadiazine was used in gelatin based electro-spun nano-fibers with various drug to polymer ratios (0, 5, 10, 15 and 20 %). sem, edx and ftir analysis showed that the continuous, bead-free, fine fibers containing silver sulfadiazine as an anti...

A number of antimicrobial silver dressings based on different substrates and silver technologies have been introduced recently. Initial in vitro testing of a new cost-effective silver dressing* showed a strong dependence between silver release and the ionic strength and organic content of the extraction solution. To answer the question if all silver dressings show similar dependence on extracti...