Diabetes mellitus is a public health problem which leads to serious complications over time. Experimentally, many herbs have been recommended for treating diabetes. In most cases, however, the recommendations are based on animal studies and limited pieces of evidence exist about their clinical usefulness. This review focused on the herbs, the hypoglycemic actions of which have been supported by...

background & aim: milk thistle [silybum marianum (l.) gaertn] is an annual or biennial plant, native to the mediterranean area, which has spread in north and south of iran. a fruit of milk thistle contains a relatively high amount (approx. 20%) of oil, which exhibits wound-healing, anti-burn, and hepatoprotective properties. experimental: in this research, a pot experiment was conducted usi...

the abilities of silybum marianum cell culture to biotransform benzaldehyde to benzyl alcohol in three culture systems were compared. callus cultures of silybum marianum were established from seedlings, and healthy suspensions and immobilized cultures grown on the murashige and skoog medium. s. marianum cells were immobilized in both agar beads and fiber cotton matrixes. benzaldehyde was fed to...

OBJECTIVE This review focuses on the medicinal plants growing and having history of folk medicine in Iran and found effective as anti free radical damage in animal or human. DESIGN Embase, Scopus, Pubmed, Web of Science, Google Scholar, IranMedex, and SID databases were searched up to 2 February 2008. The search terms were antioxidant or "lipid peroxidation" and "plant, medicinal plant, herb,...

This study revealed the optimal conditions for the Ultrasonic-Assisted Enzymatic Extraction (UAEE) of silymarin, and include: the concentration of ethanol, 50 %; enzyme concentration, 30 U/mg; liquid-solid ratio, 6:1; an extraction time of 120 min; and the ultrasonic power at 180 W. The extraction rate was 7.86 %, which is higher, by 74.67 %, than that of the silymarin extract from the Silybum ...

Purpose: To develop a nanosuspension drug delivery system to enhance the dissolution rate of Silybum marianum seeds extract.
 Methods: Central composite design was used study effect input variables (stabilizer plant extract ratio, antisolvent solvent stirring time) on dependent (mean particle size, polydispersity index (PDI) and zeta potential). The optimized formulation characterized by S...