In elucidating functionally important single-stranded loop regions derived mainly from three models in genomic hepatitis delta virus (HDV) ribozyme possessing self-cleavage activity, we have constructed several internal deletion variants of the HDV133 molecule (654-786 nt on genomic RNA) by oligonucleotide-directed mutagenesis. When self-cleavage activities were compared among variants, the HDV...

The CXCL10 gene encodes a peptide that chemoattracts a variety of leukocytes associated with type 1 and type 2 diabetes. The present study was undertaken to determine the molecular mechanisms required for expression of the CXCL10 gene in response to IL-1β and IFN-γ using rat islets and β cell lines. IL-1β induced the expression of the CXCL10 gene and promoter activity, whereas the combination o...

During the progression of prostate cancer, molecular changes occur resulting in the autocrine production of a series of neurotrophins by the malignant cells. This is coupled with expression of high-affinity cognate receptors for these ligands, termed trk receptors, by these cancer cells. The binding of the neurotrophins to their trk receptors activates the receptor's latent tyrosine kinase acti...

1 Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea 2 Medigenes Co. Ltd., 713 Suseo-dong, Gangnam-Gu, Seoul 135-539, Republic of Korea 3 Department of Biosystems, Korea Advanced Institute of Science and Technology, 3731 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of ...

207 Received October 23, 2013; revised and accepted February 13, 2014. Published online March 20, 2014; doi: 10.1620/tjem.232.207. *These two authors contributed equally to this study. Correspondence: Hee Chul Han, Ph.D., M.D., Department of Physiology, Korea University College of Medicine, 126-1 Anam-Dong 5 Ga, Sungbuk-Gu, Seoul 136-701, South Korea. e-mail: [email protected] A Single Trial o...

213 Correspondence to: Chan Heun Park, Department of Surgery, Kangdong Sacred Heart Hospital, Hallym University School of Medicine, 445, Gil 1-dong, Gangdong-gu, Seoul 134-701, Korea. Tel: 022224-2222, Fax: 02-2224-1655, E-mail: [email protected] Received November 25, 2009, Accepted January 8, 2010 *Jun Ho Park and Kee Hoon Hyun contributed equally to this work. Laparoscopic vs Transumbilical Si...

Seon-Jin Lee, Se-Kyung Bai, Kwang-Soon Lee, Seung Namkoong, Hee-Jun Na, Kwon-Soo Ha, Jeong-A Han, Sung-Vin Yim, Kwang Chang, Young-Guen Kwon, Sung Ki Lee, and Young-Myeong Kim* Vascular System Research Center and Department of Molecular and Cellular Biochemistry, Kangwon National University Biology, Chunchon 200-701, Korea; 1 Department of Pharmacology, School of Medicine, Kangwon National Univ...

Byung-Hwan Lee, Jun-Ho Lee, In-Soo Yoon, Joon-Hee Lee, Sun-Hye Choi, Mi Kyung Pyo, Sang Min Jeong, Woo-Sung Choi, Tae-Joon Shin, Sang-Mok Lee, Hyewhon Rhim, Yong-Sun Park, Ye Sun Han, Hyun-Dong Paik, Ssang-Goo Cho, Cheon-Ho Kim, Yoong-Ho Lim, Seung-Yeol Nah⁎ Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea Biomedical Research Center, KIST, Seoul ...

charges and extrinsically trapped charges in biomolecules by use of a nanogap embedded biotransistor Sungho Kim, Jae-Hyuk Ahn, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi School of Electrical Engineering and Computer Science, Division of Electrical Engineering, KAIST, Daejeon 305-701, Republic of Korea BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, an...