Development of effective treatment for hepatic metastases can be initiated by a better understanding of tumour vasculature and blood supply. This study was designed to characterise the microvascular architecture of hepatic metastases and observe the source of contributory blood supply from the host. Metastases were induced in mice by an intrasplenic injection of colon carcinoma cells (10(6) cel...

Aging associated changes in liver include reduced hepatic blood flow, increased number of stellate cells, and collagen deposits in perisinusoidal space. We tested the possibility of mitigating these changes with caloric restriction. Two-month-old mice were subjected to 30 percent caloric restriction for 12 months and then examined for the effect of caloric restriction on the sinusoidal network,...

The functional zonation of liver tissue provides a framework for studying the implantation and growth of metastatic colonies within given zones of the hepatic acini. A very exact method for calibrating the position of metastatic foci in the hepatic acini was made possible by using the succinate-dehydrogenase reaction, which reveals the functional differences of the acinar zones. In mouse livers...

Bergmann et al. [Phys. Rev. B 77, 054414 (2008)] present an analytical theory explaining the behavior of ferromagnetic cobalt nanowires with perpendicular anisotropy. This theory, which predicts a sinusoidal variation of the magnetization along the long axis of the wire, depends upon an assumption that "the magnetization is constant within a cross section of the wire." In this Comment we use mi...

Two experiments were performed to investigate subjects' ability to detect and discriminate 50-ms up-glides in frequency in several different conditions. In the first experiment, the subjects indicated which of two signals increased more in pitch. The comparison, or standard signal, was a sinusoid which increased in frequency by either 0, 250, or 500 Hz. Center frequencies were 0.5, 1, 2, 4, and...

A least-square infinite series approximation (L-SISA) technique is proposed for modeling amplitude modulated (AM) sinusoidal components of naturally occurring signals, such as those produced by traditional musical instruments. Each AM sinusoid is iteratively extracted using an analysis-by-synthesis technique and the problem of parameter estimation is linearised for least-square approximation th...

We present here an Harmonic+Noise Model (HNM) for speech synthesis. The noise part is represented by an autoregressive model whose output is pitchsynchronously modulated in energy. The harmonic part of the signal is represented by a sinusoidal model. This paper compares di erent methods for separating these two components. We then propose a method for the estimation of the sinusoidal parameters...

Introduction The axonal diameter distribution may be estimated using diffusion MRI [1], but the result can be influenced by a number of biophysical mechanisms. Axons in fiber tracts may not be straight and can have an undulating, approximately sinusoidal course. Axonal undulations are present in the peripheral nervous system and in those parts of the central nervous system that are subjected to...

The present study compares the dynamic mechanical properties and the contents of collagen and elastic fibers (oxytalan + elaunin + fully developed elastic fibers) of mice and rat lung strips. Resistance, elastance (E), and hysteresivity (eta) were obtained during sinusoidal oscillations. The relative amounts of blood vessel, bronchial, and alveolar walls, as well as the mean alveolar diameter w...

A nanoscale, synthetic perturbation was all that was required to nudge a natural, self–assembly process toward significantly higher order. Nanolithography was used to impose the perturbation which ultimately led to an organized nanoparticle array. Specifically, liquid–phase pulsed laser induced dewetting (PLiD) was used to transform metallic thin film strips into nanoparticle arrays. Initially,...