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Statins have a variety of cardioprotective properties following chronic treatment. In contrast, little is known about the acute effects. Reperfusion acutely injures the heart by activation of neutrophils as well as endothelial cells. Because statins are known to influence the processes pathogenetically involved, we hypothesized that acute application of statins attenuates the sequelae of cardia...

…………………………………………………………………………….v TABLE OF CONTENTS……………………………………………………………….vi LIST OF TABLES…………………………………………………………………….. vii LIST OF FIGURES……………………………………………………………………. viii I. INTRODUCTION…………………………………………………….. 1 II. LITERATURE REVIEW……………………………………………... 5 A. Mixing and Dispersions…………………………………………... 6 B. Grinding/Milling and Dispersants………………………………… 9 C. Pigments………………………………………………………….. 12 D. E...

Bacterial evolution toward endosymbiosis with eukaryotic cells is associated with extensive bacterial genome reduction and loss of metabolic and regulatory capabilities. Here we examined the rate and process of genome reduction in the bacterium Salmonella enterica by a serial passage experimental evolution procedure. The initial rate of DNA loss was estimated to be 0.05 bp per chromosome per ge...