We explore how global symmetry can be detected prior to segmentation and under noise and occlusion. The definition of local symmetries is extended to affine geometries by considering the tangents and curvatures of local structures, and a quantitative measure of local symmetry known as symmetricity is introduced, which is based on Mahalanobis distances from the tangent-curvature states of local ...

Exact logistic regression has become an important analytical technique, especially in the pharmaceutical industry, since the usual asymptotic methods for analyzing small, skewed, or sparse data sets are unreliable. Inference based on enumerating the exact distributions of sufficient statistics for parameters of interest in a logistic regression model, conditional on the remaining parameters, is...

In many observational longitudinal studies, the outcome of interest presents a skewed distribution, is subject to censoring due to detection limit or other reasons, and is observed at irregular times that may follow a outcome-dependent pattern. In this work, we consider quantile regression modeling of such longitudinal data, because quantile regression is generally robust in handling skewed and...

Introduction: X chromosome inactivation (XCI) is a process during which one of the two X chromosomes in female human is silenced leading to equal gene expression with males who have only one X chromosome. Here we have investigated XCI ratio in females with opioid addiction to see whether XCI skewness in women could be a risk factor for opioid addiction. Methods: 30 adult females meeting DS...

Exact logistic regression has become an important analytical technique, especially in the pharmaceutical industry, since the usual asymptotic methods for analyzing small, skewed, or sparse data sets are unreliable. Inference based on enumerating the exact distributions of sufficient statistics for parameters of interest in a logistic regression model, conditional on the remaining parameters, is...

We demonstrate that a poly(lactide-co-glycolide) (PLG) cancer vaccine can be used in combination with immune checkpoint antibodies, anti-CTLA-4 or anti-PD-1, to enhance cytotoxic T-cell (CTL) activity and induce the regression of solid B16 tumors in mice. Combination therapy obviated the need for vaccine boosting and significantly skewed intratumoral reactions toward CTL activity, resulting in ...

When covariates are measured with error, inference based on conventional generalized linear models can yield biased estimatesof regressionparameters. This problem can potentiallybe rectiŽed byusing generalizedlinear latent and mixedmodels (GLLAMM), including a measurementmodel for the relationship between observed and true covariates. However, the models are typically estimated under the assump...