BACKGROUND Although multiple studies suggest a dysregulated T-cell cytokine production in systemic lupus erythematosus, the cytokine profile in discoid lupus erythematosus (DLE) lesions is unknown. OBJECTIVES To characterize the cytokine profile in DLE by immunohistochemical and molecular methods, and to investigate the role of cytokines in the pathogenesis of DLE. DESIGN Patients were eval...

objective incontinentia pigmenti (ip) (bloch_sulzberg syndrome) is a rare neurocutaneous syndrome characterized by multisystemic involvement that is prenatally lethal in the majority of affected males and shows great clinical variability when expressed in women. the diagnosis of ip is performed based on clinical features and the family history with the support of histological findings. we repor...

INTRODUCTION Graft monitoring following vascularized composite allotransplantation (VCA) relies primarily on serial skin biopsy. However, given that VCA comprised multiple tissue types, skin biopsy may not accurately reflect rejection in other transplanted tissue. METHODS A review of the literature on episodes of both acute and chronic rejection following VCA was completed. Special attention ...

OBJECTIVE To determine the value of skin biopsies in the management of suspected graft-vs-host disease (GVHD) within 30 days of allogeneic bone marrow transplantation (BMT). DESIGN Retrospective study based on review of a BMT database. SETTING Leukemia/BMT ward of a tertiary care, university teaching hospital. PATIENTS One hundred and eighty-seven consecutive patients who received allogen...

Skin biopsy images can reveal causes and severity of many skin diseases, which is a significant complement for skin surface inspection. Automatic annotation of skin biopsy image is an important problem for increasing efficiency and reducing the subjectiveness in diagnosis. However it is challenging particularly when there exists indirect relationship between annotation terms and local regions o...

The skin biopsy is a simple procedure that can assist with the diagnosis of cutaneous disorders. More errors are made from failing to biopsy promptly than from performing unnecessary biopsies. Properly performed, it may confirm a diagnosis, remove cosmetically unacceptable lesions, and provide definitive treatment for a number of skin conditions. Skin biopsies are unique because the lesion can ...

Sentinel lymph node biopsy is performed routinely in melanoma because lymph node progression has been shown to be the strongest predictor of survival. Given the proven relevance of biopsy findings in this type of skin cancer, the procedure has been extended to other skin tumors. Experience in nonmelanoma cancer is much more limited and the prognostic usefulness of biopsy results remains to be s...

BACKGROUND To better understand skin biopsy practice among primary care providers, we sought to describe (1) the type and variability of skin lesions biopsied within a defined population, (2) the providers' previous skin cancer experience in clinical practice, and (3) how providers are alerted to the lesions. METHODS Our study was based upon 1215 skin biopsies done by family physicians, inter...

Background: Although opioids suppressive effects on immune system function have been reported, this study demonstrates inflammatory reactions, such as production of pro-inflammatory cytokines and suppression of anti-inflammatory cytokines, are the main causes at organ’s allotransplantation rejection in chronic morphine-treated recipients. Methods: 28 rats were categorized in 4groups through int...

Skin issues are among the most common reasons pet owners seek veterinary care (1). Most will respond to treatment, but when treatment fails, a skin biopsy is often the next step. Skin biopsies are a very useful tool and have the potential to provide a great deal of information to make a specific diagnosis and to guide treatment. Unfortunately many biopsies come back “non-specific findings” or “...