Intradermal inoculation of metacyclic forms of Trypanosoma congolense propagated in vitro caused skin reactions in goats similar to the local skin reaction (chancre) induced by the bite of an infected tsetse fly. The onset, size and duration of these local skin reactions were dose-dependent. Whereas one cultured metacyclic T. congolense was sufficient to cause a local skin reaction in a goat, o...

Topical 5- Fluorouracil (5-FU) is used more frequently to treat actinic keratosis. We are presenting a skin reaction as a side effect of this medication. Treatment for such cases of 5-FU-induced skin reactions is based on proper skin care and treatment of any superimposed infections. Medical providers should be aware of such side effects to provide their patients with proper instructions to avo...

Mr. C is a 74-year-old male with colon cancer who originally was treated with surgery and 5-fluorouracil-based chemotherapy. One year after Mr. C completed treatment, paramedics were called to transport him to the emergency room (ER) after he experienced a grand mal seizure in his home. An 18-gauge catheter was placed in his right hand in the ambulance for IV access. He was given 10 mg IV diaze...

The present paper describes the results observed when pneumococcus antigen, prepared in the same way as for the anaphylactic experiments described in the preceding article, 1 was injected intracutaneously into a series of pneumonia patients, and into controls. The same method has been employed by Clough, 2 who reached the conclusion that these injections had in general an irritant effect, and t...

Sir—Although Giuliani et al. [1] refer to pinta as a separate disorder, and it has been suggested that its pathology is limited to the skin, review of the literature on pinta actually revealed the presence of bone involvement [2]. That pattern of bone involvement in the pinta-afflicted individuals was no different from the endemic pattern of treponematoses found in the area [3]. Pinta simply ap...

EXAMINATION The erythematous papulo-squamous lesions, some with polycyclic and annular configurations, were distributed symmetrically on the buttocks, arms, and legs, and involved both extensor and flexural areas. The lesions felt infiltrated. Grattage was negative. There was no scarring, no other skin or mucous membrane lesion, and no lymphadenopathy. Sensory reactions were normal and there wa...

Occupational asthma due to platinum salts is a frequent disease in platinum refineries. The diagnosis is based upon a history of work related symptoms and a positive skin prick test with platinum salts. Bronchial provocation tests have not been performed in epidemiological studies because the skin test is believed to be highly specific and sensitive. As no reliable data about this issue current...

Quantitative determination of the etheral sulphuric acids in the granules of the mast cells in small pieces of tissue would be of considerable value, but unfortunately no micromethods for such extractions and analyses have yet been devised. As matters stand, morphologists have thus to perform a rough estimation of the number of mast cells and their granule content from microscopic slides. The c...

Between 20% and 35% of patients with systemic sarcoidosis have skin lesions. One of the unusual cutaneous presentations of sarcoidosis is a granulomatous tattoo reaction that may present alone or with other features of sarcoidosis. We present a case of sarcoidosis whom presented with multiple nodules on tattood skin accompanied with facial pulsy, parotid enlargement and uveitis.

PURPOSE Safetac-based soft silicone dressings used in a management setting decrease the severity of radiation-induced acute skin reactions but do not affect moist desquamation rates. Here we investigate the prophylactic use of another Safetac product, Mepitel Film, on moist desquamation rates. MATERIAL AND METHODS A total of 80 breast cancer patients receiving radiation therapy were recruited...