objective(s): although tumor necrosis factor-related apoptosis-inducing ligand (trail) can selectively induce apoptosis in tumor cells, more than half of tumors including non-small cell lung cancer (nsclc) exhibit trail-resistance. the purpose of this study was to determine whether subtoxic-dose cisplatin and trail could synergistically enhance apoptosis on nsclc cells and investigate its under...

conclusion the technical performance of pet scan is significantly higher than similar technologies for staging and treatment of nsclc. in addition, it might slightly improve the treatment process and lead to a small level of increase in the quality adjusted life year (qaly) gained by these patients making it cost-effective for the treatment of nsclc. results the total annual running cost of a p...

Small Cell Lung Cancer (SCLC) is a low-differentiated neuroendocrine tumor with rapid growth, early metastasis and sensitivity to radiotherapy chemotherapy. It highly recurrence rate. And there lacking effective treatment now. As an active research direction at present, anti-angiogenic drugs are not only widely used in non-small cell lung cancer other tumors, but also have certain effects small...

Background: Lung cancer is the most common cause of cancer death worldwide with an annual mortality rate of more than 1.3 million worldwide. We aimed to analyze the clinicopathological features of patients with non-small-cell lung cancer (NSCLC) in west of Iran. Methods: 64 patients with NSCLC who referred to our clinic were analyzed. Sex, age, histopathology, location of the tumor, treatment,...

Background: Lung cancer is a leading cause of cancer-related mortality worldwide. The purpose our meta-analysis was to assess the risk factors for brain metastases (BM) in patients with non-small cell lung (NSCLC).

Introduction: Despite improvements in the diagnosis and treatment of lung cancer in the past two decades, it has remained the most common cause of death from cancer worldwide. Among all genes that are mutated in lung cancer, TP53 located on chromosome 17P13/1 has a significant diagnostic and prognostic value. TP53 mutations have been extensively studied in lung cancer and TP53 mutational spectr...

Secondary Metabolites of Soil Actinomycetes, UTMC 676 and 919, Induces Apoptosis in Human Non‑Small-Cell Lung Cancer Cell Line