Advanced atherosclerotic plaques demonstrate extensive DNA damage, seen in smooth muscle cells, endothelial cells, macrophages and in circulating cells, and in both nuclei and mitochondria. DNA damage includes both singleor double-stranded breaks, deleted sections of DNA, nucleotide modifications, and extrusions of DNA from the nucleus (micronuclei). Reactive oxygen species (ROS) induce a varie...

Detecting and modelling structural changes in GARCH processes have attracted a great amount of attention in time series econometrics over the past few years. In this paper, we …rst generalize Dahlhaus and Subba Rao (2006 2008)’s time-varying ARCH processes to time-varying GARCH processes and derive the consistency and asymptotic normality of the weighted quasi maximum likelihood estimator of th...

  Bimorph piezoelectric cantilevered (BPC) actuators have recently received a great deal of attention in a variety of micro-electromechanical systems (MEMS) applications. Dynamic modeling of such actuators needs to be improved in order to enhance the control performance. Previous works have usually taken transv...

Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...

Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...

The formation and evaporation of small AdS black holes in a theory with holographic dual is governed by the usual rules quantum mechanics. eigenstate thermalization hypothesis explains validity semiclassical gravity for local bulk observables can be used to quantify magnitude corrections approximation. produces basis hole states finite energy width, that are smooth functions on classical phase ...