نتایج جستجو برای: snp array
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dbSNP of NCBI, providing the information for SNP genotype and frequency of many populations. However, many previous association studies provide only the SNP nucleotide position or primer sequences, without giving an SNP ID of NCBI. In this study, we built the dbSNP, SNP fasta and SNP flanking marker databases for the rat, mouse and human organisms from the NCBI databases. Boyer-Moore algorithm,...
MOTIVATION Modern strategies for mapping disease loci require efficient genotyping of a large number of known polymorphic sites in the genome. The sensitive and high-throughput nature of hybridization-based DNA microarray technology provides an ideal platform for such an application by interrogating up to hundreds of thousands of single nucleotide polymorphisms (SNPs) in a single assay. Similar...
Cytogenetic analysis is essential for the diagnosis and prognosis of hematopoietic neoplasms in current clinical practice. Many hematopoietic malignancies are characterized by structural chromosomal abnormalities such as specific translocations, inversions, deletions and/or numerical abnormalities that can be identified by karyotype analysis or fluorescence in situ hybridization (FISH) studies....
BACKGROUND Genomic complexity can predict the clinical course of patients affected by chronic lymphocytic leukemia (CLL) with a normal FISH. However, large studies are still lacking. Here, we analyzed a large series of CLL patients and also carried out the so far largest comparison of FISH versus single-nucleotide polymorphism (SNP) array in this disease. PATIENTS AND METHODS SNP-array data w...
314 Genomic divergence of indicine and taurine cattle identified through high-density SNP genotyping. L. R. Porto-Neto2, T. S. Sonstegard*1, G. Liu1, D. Bickhart3, C. Gondro6, M. V. da Silva4, Y. T. Utsunomiya5, J. F. Garcia5, and C. P. Van Tassell1, 1USDA, ARS, Bovine Functional Genomics Laboratory, Beltsville, MD, 2University of Queensland, Gatton, Queensland, Australia, 3USDA, ARS, Animal Im...
Figure S1 (Related to Figure 1). A. Genome graph showing distribution of SNPs across the genome. B. Estimated marker informativeness for an F2 intercross between wild caught sticklebacks. C. Histogram showing the distribution of average pairwise FST between global populations. Figure S2 (Related to Figure 3). A self dot-plot showing sequence similarity of a 390kb region on chromosome X with two...
High-density SNP arrays for genome-wide assessment of allelic variation have made high resolution genetic characterization of crop germplasm feasible. A medium density array for apple, the IRSC 8K SNP array, has been successfully developed and used for screens of bi-parental populations. However, the number of robust and well-distributed markers contained on this array was not sufficient to per...
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