BACKGROUND AND PURPOSE The reduced incidence, morbidity, and mortality of stroke among humans with strong social support have been well-documented; however, the mechanisms underlying these socially mediated phenomena remain unknown, but may involve oxytocin (OT), a hormone that modulates some aspects of social behavior in humans and other animals. METHODS In the present study, adult male mice...

Submitted Chapter 6 104 Chronic stress is thought to be an important factor in the aetiology of depression, whereas social support has stress-reducing properties and a positive influence on the course of a depressive episode. 21 Days of chronic footshock stress was used as a model for affective disorders in rats and group housing of rats could provide a suitable model for social support to stud...

Social isolation is a widespread problem with which community oriented social workers are increasingly confronted. Mutual support groups can be used by to socially isolated people. This paper reports on participatory action research into the method Support-nets. In this method, mutual group set up specifically for people that share of isolation. The aim study was gain insight in how participant...

This paper considers the needs of an ageing population and the implications for Human Computer Interaction (HCI) research. The discussion is structured around findings from interviews with medical and care professionals and older people. Various technologies are being successfully used to monitor for falls and other emergencies, and also to assess and manage risk. The design of this technology ...

The traditional Japanese medicine yokukansan has an anxiolytic effect, which occurs after repeated administration. In this study, to investigate the underlying mechanisms, we examined the effects of repeated yokukansan administration on serotonin 1A (5-HT1A) receptor density and affinity and its expression at both mRNA and protein levels in the prefrontal cortex (PFC) of socially isolated mice....

To evaluate the gender-specific impact of social exclusion on the mortality of older Japanese adults, we performed a prospective data analysis using the data of the Aichi Gerontological Evaluation Study (AGES). In AGES, we surveyed functionally independent residents aged 65 years or older who lived in six municipalities in Aichi prefecture, Japan. We gathered baseline information from 13,310 re...

Stressful social experiences early in life, such as maternal separation and social isolation, have enduring effects on the development of the brain and behavior. In the present study in socially monogamous male prairie voles (Microtus ochrogaster), we found that following 6 weeks of social isolation after weaning males spent more time in the closed arms and less time in the open arms during an ...

It is well documented that psychological stress impairs wound healing in humans and rodents. However, most research effort into influences on wound healing has focused on factors that compromise, rather than promote, healing. In the present study, we determined if positive social interaction, which influences hypothalamic-pituitary-adrenal (HPA) axis activity in social rodents, promotes wound h...

Major depressive disorder (MDD) is a debilitating psychiatric mood disorder that affects millions of individuals globally. Our understanding of the biological basis of MDD is poor, and current treatments are ineffective in a significant proportion of cases. This current situation may relate to the dominant rodent animal models of depression, which possess translational limitations due to limite...