Received 10 January 2011 Revised 26 January 2011 Accepted 28 January 2011 Early online 29 January 2011 Print 31 January 2011 Fluoride is known to cross the blood-brain barrier and alter the structure and function of neural tissue. There are few authoritative reports on neurodegenerative changes in hippocampus, neocortex, cerebellum, spinal cord and sciatic nerve in fluoride intoxication. We rep...

OBJECTIVE This study evaluated the bioavailability of fluoride after topical application of a dual-fluoride varnish commercially available in Brazil, when compared to Duraphat. MATERIAL AND METHODS The urinary fluoride output was evaluated in seven 5-year-old children after application of the fluoride varnishes, in two different phases. In the first phase (I), children received topical applic...

BACKGROUND AND AIMS Dental caries still remains a major problem in the field of oral and dental health and its prevention is more important than its treatment. Fluoride plays a significant role in prevention of caries, and improving oral and dental health. One of the common ways of fluoride use is the use of a fluoride-containing mouthwash, the most important of which in use is 0.2% sodium fluo...

Fluorosis is a dreaded condition caused due to high exposure of sodium fluoride in drinking water. The aim of this study was to use sensitive biomarkers to evaluate damage to adrenal gland after fluoride exposure. Recently, weaned Wistar rats were exposed to 100, 200 and 300 ppm fluoride concentrations in drinking water for a period of 20 and 40 days. At the end of exposure period, oxidative st...

Rice rats were distributed by littermate into four experimental groups as follows: stannous fluoride (0.4%), iodine-sodium iodide (1.0%), a combination of iodine-sodium iodide and stannous fluoride, and a distilled water control. Each rat was treated by swabbing the molar teeth daily. All rats were fed diet 2000 and double-distilled water ad libitum, and were sacrificed after 9 weeks. Root surf...

Sodium fluoride caused inhibition of growth rate and growth levels of Streptococcus mutans with glucose as the primary energy and carbon source. Stannous fluoride increased growth lag nad caused a much greater inhibition of growth rate than did sodium fluoride. Neither compound was found to be bactericidal when culture viability was measured after 6 days of incubation. Leuconostoc mesenteroides...

BACKGROUND Fluoride toothpastes presumably offer some protection against acid erosion. However, uncertainty exists towards fluoride's efficacy relatively to the concentration and the type of chemical compound used. This in vitro study evaluated the relative efficacy of toothpastes containing sodium fluoride in different concentrations or a stabilized stannous fluoride/sodium fluoride system on ...

OBJECTIVE To test whether slow-release sodium fluoride inhibits spinal fractures and is safe to use. DESIGN Placebo-controlled randomized trial. INTERVENTIONS Slow-release sodium fluoride, 25 mg twice daily, in four 14-month cycles (12 months receiving sodium fluoride followed by 2 months not receiving it) compared with placebo. Calcium citrate, 400 mg calcium twice daily, continuously in b...

BACKGROUND As a low-cost and easily operated treatment, the use of professionally applied topical fluoride was approved for preventing dental caries and remineralising early enamel caries or white spot lesions. It is also used to arrest dentine caries. The aim of this study is to investigate the clinical efficacy of professional fluoride therapy in remineralising and arresting caries in childre...

The purpose of this study was to assess the anticalculus efficacy and long-term safety of a new stannous fluoride dentifrice containing sodium hexametaphosphate. This trial was a randomized, double-blind, parallel-group, 6-month study where, after a prophylaxis, subjects brushed twice daily with either a stabilized 0.454% stannous fluoride/13% sodium hexametaphosphate dentifrice (Crest Pro-Heal...