abstract: warfarin is the most commonly used oral anticoagulant drug in clinical practice with extreme inter and intra-individual variation in pharmacokinetic properties. na valproate, a broad spectrum anticonvulsant agent, is best known for its enzyme inhibition properties and also displacement of protein binding sites. interaction between warfarin and psychotropic drugs including valproate ar...

drug-food interactions can increase or decrease drug effects, resulting in therapeutic failure or toxicity. activities that reduce these interactions play an important role for clinical pharmacists. this study was planned and performed in order to determine the role of clinical pharmacist in the prevention of absorption drug-food interactions through educating the nurses in a teaching hospital ...

data collected in 2012 on 400 chickens were subjected to two-way analyses of variance to estimatebody weight, morphometric traits as well as the correlationbetween body weight and morphometric traitsin isa brown and ilorin ecotypechickens. the studied morphometric traits were comb length, beak length,head length, neck length, body length, wing length, shank length, thigh length, toe length, bre...

the interaction of biomolecules with carbon nanotubes (cnts) has generated a great deal ofinterest in the past few years. the interaction between b-form single-strand dna (ssdna) andsingle-walled carbon nanotubes (swcnts) is a subject of intense current interest; however thereare a relatively small number of papers in the literature dealing with interaction of dna andswcnts. in this work we inv...

meningococcal disease remains a significant global public health and is unique among causes of bacterial meningitis and sepsis where it not only causes sporadic disease but also outbreaks. meningococcal disease has a rapid onset with high mortality. the understanding of immunopathogenesis is crucial for development of novel therapeutic strategies and vaccines designed against meningococcal dise...

concomitant use of several drugs by icu( intensive care unit) patients is often unavoidable. in these patients, pharmacokinetic drug interactions are very likely. the current study was designed to evaluate these interactions in patients hospitalized in an icu of a teaching hospital in tehran, iran. a questionnaire was designed and used to collect study data. the study was done in the icu of a t...

background alcoholic hepatitis (ah) is an acute manifestation of alcoholic liver disease with high mortality rates. objectives our aim was to study the molecular mechanisms of ah. materials and methods the differentially expressed genes (degs) in liver between ah and control cases were identified by analyzing the gse28619 microarray data using t-test. the kyoto encyclopedia of genes and genomes...

this study was performed to determine the effect of injecting selenium into pregnant heifers at the last stage of gestation on the serum se, cu, zn and fe status of the heifers and their calves. fifty holstein heifers were randomly assigned to one of five treatments. four and two weeks before the expected time of calving, the heifers were injected intramuscularly 10 ml (t1), 20 ml (t2), 30 ml (...