Solid lipid nanoparticle (SLN) delivery systems have a wide applicability in the delivery of phyto-bioactive compounds to treat various chronic diseases, including diabetes, cancer, obesity and neurodegenerative diseases. The multiple benefits of SLN delivery include improved stability, smaller particle size, leaching prevention and enhanced lymphatic uptake of the bioactive compounds through o...

objective(s): in the current study, sunscreen and moisturizing properties of solid lipid nanoparticle (sln)-safranal formulations were evaluated. materials and methods:series of sln were prepared using glyceryl monostearate, tween 80 and different amounts of safranal by high shear homogenization, and ultrasound and high-pressure homogenization (hph) methods. sln formulations were characterized ...

From last thirty years, solid lipid nanoparticles (SLNs) gain much importance as drug delivery vehicle for enhanced of the drugs, proteins, nutraceuticals and cosmetics. SLNs defined a submicron size range nanoparticle with below 1000 nm are mainly composed lipids surfactants, capable incorporating both lipophilic hydrophilic drugs. also used controlled systems, targeted altered therapeutic eff...

BACKGROUND Lipid-based dispersion of nanoparticles provides a biologically inspired route to designing therapeutic agents and a means of reducing nanoparticle toxicity. Little is currently known on how the presence of nanoparticles influences lipid vesicle stability and bilayer phase behavior. In this work, the formation of aqueous lipid/nanoparticle assemblies (LNAs) consisting of hydrophobic ...

The combined effects of nanoparticle and magnetic field on the nonlinear Jeffery-Hamel flow are analyzed in the present study. The basic governing equations are solved analytically to nonlinear ordinary differential equation using perturbation method together with a semi-numerical analytical technique called Hermite- Padé approximation. The obtained results are well agreed with that of the Adom...

In this work, a theoretical model describing the interaction between a positively or negatively charged nanoparticle and neutral zwitterionic lipid bilayers is presented. It is shown that in the close vicinity of the positively charged nanoparticle, the zwitterionic lipid head groups are less extended in the direction perpendicular to the membrane surface, while in the vicinity of the negativel...

Low-oral bioavailability as a consequence of low-water solubility drugs is challenging for formulation scientists in the development new pharmaceutical products. This review aims to highlight relevant considerations when implementing rational strategy lipid-based oral drug delivery systems and discuss shortcomings challenges current classification these such nanoemulsion, Solid lipid nanopartic...